2011 Fiscal Year Final Research Report
The development of the new therapy by kinetic analysis and the redox adjustment of the oxidative stress in cerebrovascular disorder.
| Project/Area Number |
21591856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
YOSHIDA Kenji 岩手医科大学, 医学部, 講師 (10316367)
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| Co-Investigator(Renkei-kenkyūsha) |
OGASAWARA Kuniaki (00305989)
KUBO Yoshitaka (00316366)
KASHIMURA Hiroshi (20398473)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳血管障害 |
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| Research Abstract |
We analyzed the effect that cerebral ischaemia/reperfusion in ischemic cerebrovascular disease and the surgical treatment, made clear that hyperperfusion after the recanalization correlated with degree of cerebral ischaemia. The improvement of a postoperative cognitive function did that we correlated with improvement the benzodiazepine receptor function of the brain cortex nerve cells. Also, we reported the first time that these phenomenon were reversible changes. We established the new examination technique of the SPECT for cerebral metabolism that could evaluate without use the frequent medicine of the side effect.
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[Journal Article] Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases : comparison with cerebrovascular reactivity to acetazolamide and cerebral blood flow SPECT imaging2012
Author(s)
Kuroda H, Ogasawara K, Suzuki T, Chida K, Aso K, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Ogawa A.
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Journal Title
Clin Nucl Med
Volume: 37
Pages: 135-240
Peer Reviewed
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[Journal Article] Preoperative central benzodiazepine receptor binding potential and cerebral blood flow images on SPECT predict development of new cerebral ischemic events and cerebral hyperperfusion after carotid endarterectomy2011
Author(s)
Sato Y, Ogasawara K, Kuroda H, Suzuki T, Chida K, Fujiwara S, Aso K, Kobayashi M, Yoshida K, Terasaki K, Ogawa A.
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Journal Title
J Nucl Med
Volume: 52
Pages: 1400-1407
Peer Reviewed
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[Journal Article] Brain temperature measured by using proton MR spectroscopy predicts cerebral hyperperfusion after carotid endarterectomy2010
Author(s)
Murakami T, Ogasawara K, Yoshioka Y, Ishigaki D, Sasaki M, Kudo K, Aso K, Nishimoto H, Kobayashi M, Yoshida K, Ogawa A.
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Journal Title
Radiology
Volume: 256
Pages: 924-931
Peer Reviewed
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[Journal Article] Brain temperature measured using proton MR spectroscopy detects cerebral hemodynamic impairment in patients with unilateral chronic major cerebral artery steno-occlusive disease : comparison with positron emission tomography2009
Author(s)
Ishigaki D, Ogasawara K, Yoshioka Y, Chida K, Sasaki M, Fujiwara S, Aso K, Kobayashi M, Yoshida K, Terasaki K, Inoue T, Ogawa A.
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Journal Title
Stroke
Volume: 40(9)
Pages: 3012-3016
Peer Reviewed
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