2011 Fiscal Year Final Research Report
a role of glial cells in the central nervous system to prevent retrograde degeneration of the facial nucleus and a mechanism for axonal regeneration
| Project/Area Number |
21591859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | facial motoneuron / retrograde degeneration / axonal injury / brainstem / glial cell |
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| Research Abstract |
Axonal injury models throughout the facial nerve from brainstem to the target was utilized to analyze the mechanism of retrograde motoneuron degeneration and seek the preventing factors against the neuronal loss. Peripheral injury induced little motoneuron degeneration, but brainstem injury showed massive and rapid degeneration resulting in only 3% neuronal survival on day 28.Peripheral nerve autograft induced 8-times axonal survival and erythropoietin 3-times, but no other neuroprotective factors found so far. Nitric oxide was supposed to be related to the mechanism of neuronal loss but apoptosis was not. The neuroprotective mechanism for retrograde degeneration might give us the cue for CNS regeneration.
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