Establishment and Clinical application of Neurogenesis Imaging Technique

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
• Co-Investigator(Kenkyū-buntansha): TANAKA Chuzo 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541) ; UMEDA Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (60223608) ; WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
• Project Period (FY): 2009 – 2011
• Keywords: 神経再生 / MRI / マンガン / 脳虚血

Research Abstract

The purpose of these studies is to examine the"neurogenesis imaging"technique using MRI and propose the clinical application. We have detected reactive gliosis as a result of focal ischemia by the manganese-enhanced MRI(MEMRI) technique. The increase of manganese accumulation is supposed to be due to increased uptake of manganese by hyperactive glia cells or to high density of glial cells. In the transient forebrain ischemia(cerebral ischemia without infarction), excessive manganese accumulation in the CA1 was observed on 3 days and 10 days after ischemia. The agreed change was found at 10 days as a result of astrocyte activation to be obtained by immunohistological staining for GFAP although the 3 days result did not accord.

Research Products

• [Journal Article] Diffusion-weighted Spectroscopic Imagingによる脳虚血モデルラットの解析 (2012)
  • Author(s): 尾藤良孝, 河合裕子, 平田宏司, 恵飛須俊彦, 大竹陽介, 平田智嗣, 白猪亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Journal Title: 磁気共鳴学会雑誌 Volume: Vol.32(1) Pages: 17-20
  • Peer Reviewed
• [Journal Article] Inconsistency and uncertainty of the human visual area loci following surface-based registration : probability and entropy maps (2012)
  • Author(s): Yamamoto H, Fukunaga M, Takahashi S, Mano H, Tanaka C, Umeda M, Ejima Y
  • Journal Title: Human Brain Mappinng Volume: Vol.33 Pages: 121-129
  • DOI: DOI:10.1002/hbm.21200.
  • Peer Reviewed
• [Journal Article] Preparation of polymer-based multimodal imaging agent to visualize the process of bone regeneration (2011)
  • Author(s): Liu J, Jo JI, Kawai Y, Aoki I, Tanaka C, Yamamoto M, Tabata Y
  • Journal Title: J Control Release Volume: Vol.157(3) Pages: 398-405
  • DOI: DOI:10.1016/j.jconrel.2011.09.090.
  • Peer Reviewed
• [Journal Article] Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats (2011)
  • Author(s): Y Yasuda, T Shimoda, K Uno, N Tateishi, S Furuya, Y Tsuchihashi, Y Kawai, S Naruse and S Fujita
  • Journal Title: J Neuroinflammation Volume: Vol.8 Pages: 70-80
  • DOI: DOI:10.1186/1742-2094-8-70.
  • Peer Reviewed
• [Journal Article] マンガン造影磁気共鳴画像法(MEMRI)の実際 (2011)
  • Author(s): 青木伊知男, 河合裕子
  • Journal Title: 磁気共鳴学会雑誌 Volume: Vol.31 Pages: 1-19
  • Peer Reviewed
• [Journal Article] In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging (2011)
  • Author(s): Morisaki S, Kawai Y, Umeda M, Nishi M, Oda R, Fujiwara H, Yamada K, Higuchi T, Tanaka C, Kawata M, Kubo T
  • Journal Title: J Magn Reson Imaging Volume: Vol.33 Pages: 535-542
  • DOI: DOI:10.1002/jmri.22442.
  • Peer Reviewed
• [Journal Article] Diffusion-weighted line-scan echo-planar spectroscopic imagingによる代謝物拡散計測の精度向上 (2010)
  • Author(s): 尾藤良孝, 平田宏司, 恵飛須俊彦, 河合裕子, 大竹陽介, 平田智嗣, 白猪亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Journal Title: 磁気共鳴学会雑誌 Volume: Vol.30 Pages: 36-38
  • Peer Reviewed
• [Journal Article] Nural correlates of color-selective metacontrast in human early retinotopic areas (2010)
  • Author(s): Maeda K, Yamamoto H, Fukunaga M, Umeda M, Tanaka C, Ejima Y
  • Journal Title: J Neurophysiol Volume: Vol.104 Pages: 2291-2301
  • DOI: DOI:10.1152/jn.00923.
  • Peer Reviewed
• [Journal Article] Detection of necrotic neural response in super-acute cerebral ischemia using activity-induced manganese-enhanced(AIM) MRI (2010)
  • Author(s): Inoue Y, Aoki I, Mori Y, Kawai Y, Ebisu T, Osaka Y, Houri T, Mineura K, Higuchi T, Tanaka C
  • Journal Title: NMR Biomed Volume: Vol.23(3) Pages: 304-12
  • DOI: DOI:10.1002/nbm.1464.
  • Peer Reviewed
• [Journal Article] In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging (2010)
  • Author(s): Kawai Y, Aoki I, Umeda M, Higuchi T, Kershaw J, Higuchi M, Silva AC, Tanaka C
  • Journal Title: NeuroImage Volume: Vol.49(4) Pages: 3122-31
  • DOI: DOI:10.1016/j.neuroimage.2009.11.005.
  • Peer Reviewed
• [Presentation] Diffusion-weighted Spectroscopic Imagingによる脳虚血モテルラットの解析 (2011)
  • Author(s): 尾藤良孝, 河合裕子, 平田宏司, 恵飛須俊彦, 大竹陽介, 平田智嗣, 白猪亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 福岡県小倉
  • Year and Date: 2011-10-01
• [Presentation] 筋組織中における水分子の動態解析-筋収縮時の評価- (2011)
  • Author(s): 渡邉康晴, 木村啓作, 梅田雅宏, 河合裕子, 樋口敏宏, 田中忠蔵
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 福岡県小倉
  • Year and Date: 2011-09-30
• [Presentation] Diffusion Tensor Spectroscopic Imaging of Rat Brains (2011)
  • Author(s): Y. Bito, Y. Kawai, K. Hirata, T. Ebisu, T. Shirai, S. Hirata1, Y. Soutome, H. Ochi, M. Umeda, T. Higuchi, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-11
• [Presentation] In vivo Detection of Glial Activity after Transient Forebrain Ischemia using Manganese-enhanced MRI (2011)
  • Author(s): Y. Kawai, Y. Yasuda, N. Tateishi, M. Umeda, Y. Watanabe, T. Higuchi, S. Furuya, S. Naruse, S. Fujita, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-10
• [Presentation] Diffusion-weighted Spectroscopic Imaging of Rat Brains After Middle Cerebral Artery Occlusion (2011)
  • Author(s): Y. Bito, Y. Kawai, K. Hirata, T. Ebisu, T. Shirai, S. Hirata1, Y. Soutome, H. Ochi, M. Umeda, T. Higuchi, and C. Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-05-09
• [Presentation] Detailed megnetic resonance imaging for surgery of unruptured intracranial aneurysm (2011)
  • Author(s): Tenjin H, Takadou M, Mandai A, Nanto M. Osaka Y, Nakahara Y, Umeda M, Higuchi T
  • Organizer: Joint EANS Annual-Meeting-4th World ICH Conference
  • Place of Presentation: Newcastle Gateshead, UK
  • Year and Date: 2011-05-04
• [Presentation] Detection of Signal Enhancement in the Hippocampus after Transient Forebrain Ischemia using Manganese-enhanced MRI (2010)
  • Author(s): Kawai Y, Yasuda Y, Tateishi N, Umeda M, Watanabe Y, Higuchi T, Furuya S, Naruse S, Fujita S, Tanaka C
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100900
• [Presentation] Water Suppression for Diffusion-Weighted Line-Scan Echo-Planar Spectroscopic Imaging (2010)
  • Author(s): Bito Y, Hirata K, Ebisu T, Kawai Y, Otake Y, Hirata S, Shirai T, Soutome Y, Ochi H, Umeda M, Higuchi T, Tanaka C
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100500
• [Presentation] Motion Artifact Reduction Using Bipolar Diffusion Gradients in Diffusion-Weighted Echo-Planar Spectroscopic Imaging (2010)
  • Author(s): Bito Y, Hirata K, Ebisu T, Kawai Y, Otake Y, Hirata S, Shirai T, Soutome Y, Ochi H, Umeda M, Higuchi T, Tanaka C
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100500
• [Presentation] Detection of Brain Activity During Chronic Pain Using Activity-Induced Manganese-Enhanced MRI in the Rat (2010)
  • Author(s): Kawai Y, Umeda M, Watanabe Y, Higuchi T, Naruse S, Tanaka C
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100500
• [Presentation] Correction of Eddy Currents for Time-domain-interleaved Blipped-phase-encoding Echo-planar Spectroscopic Imaging (2010)
  • Author(s): Bito Y, Hirata K, Hirata S, Shirai T, Ebisu T, Kawai Y, Otake Y, Soutome Y, Ochi H, Umeda M, Higuchi T, Tanaka C
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100500
• [Presentation] 心拍による腎動脈の血流速度と腎皮質のADCの関係 (2010)
  • Author(s): 梅田雅宏, 森勇樹, 吉岡芳親, 河合裕子, 渡辺康晴, 村瀬智一, 中井麻衣, 樋口敏宏, 田中忠蔵
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2010-10-01
• [Presentation] オボアルブミン水溶液の熱変性によるMTR上昇とT1短縮効果の関係 (2010)
  • Author(s): 中井麻衣, 梅田雅宏, 渡辺康晴, 河合裕子, 樋口敏宏, 田中忠蔵
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2010-10-01
• [Presentation] Bipolar Diffusion GradientsによるDiffusion-weighted Spectroscopic Imagingの体動アーティファクト抑制 (2010)
  • Author(s): 尾藤良孝, 平田宏司, 恵飛須俊彦, 河合裕子, 大竹陽介, 平田智嗣, 白猪亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2010-09-30
• [Presentation] 一過性前脳虚血による海馬におけるグリア活性の検討 (2010)
  • Author(s): 河合裕子, 安田ゐう子, 立石成人, 梅田雅宏, 渡辺康晴, 樋口敏宏, 古谷誠一, 成瀬昭二, 藤田晢也, 田中忠蔵
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2010-09-30
• [Presentation] Observation of muscular characteristic using diffusion weighted MRI and 1H spectroscopic imaging (2010)
  • Author(s): Umeda M, Watanabe Y, Kimura K, Kawai Y, Higuchi T, Tanaka C
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市
  • Year and Date: 2010-05-19
• [Presentation] Manganese-enhanced MRIを用いた虚血脳における組織変化の検出 (2009)
  • Author(s): 河合裕子, 青木伊知男, 梅田雅宏, 樋口敏宏, 樋口真人, Afonso C Silva, 田中忠蔵
  • Organizer: 日本脳循環代謝学会総会
  • Place of Presentation: 大阪府豊中市
  • Year and Date: 20091119-20
• [Presentation] Increased intramuscular pressure during venous occlusion decreases the mobility of the intramuscular water with indentation (2009)
  • Author(s): Keisaku, Kimura, Yasuharu, Watanabe, Kenji, Katayama, Masahiro, Umeda, Tadashi, Yano
  • Organizer: International Congress of Physiological Science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090727-0801
• [Presentation] A new imaging of muscle deformation applied electrical stimulation using MRI (2009)
  • Author(s): Yasuharu, Watanabe, Masahiro, Umeda, Keisaku, Kimura, Yuko, Kawai, Toshihiro, Higuchi, Chuzo, Tanaka
  • Organizer: International Congress of Physiological Science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090727-0801
• [Presentation] Dynamic DTI During Muscle Contraction by Electrical Stimulation (2009)
  • Author(s): Watanabe, Yasuharu, Kimura, Keisaku, Umeda, Masahiro, Higuchi, Toshihiro, Tanaka, Chuzo
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20090418-24
• [Presentation] Parallel Line-scan Echo-planar Spectroscopic Imaging (2009)
  • Author(s): Bito, Yoshitaka, Shirai, Toru, Hirata, Satoshi, Taniguchi, Yo, Hirata, Koji, Otake, Yosuke, Soutome, Yoshihisa, Ochi, Hisaaki, Ebisu, Toshihiko, Kawai, Yuko, Umeda, Masahiro, Higuchi, Toshihiro, Tanaka, Chuzo
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20090418-24
• [Presentation] Diffusion-Weighted Line-Scan Echo-Planar Spectroscopic Imaging for Improved Accuracy in Metabolite Diffusion Imaging (2009)
  • Author(s): Bito Yoshitaka, Hirata Koji, Ebisu Toshihiko, Kawai Yuko, Otake Yosuke, Hirata Satoshi, Shirai Toru, Soutome Yoshihisa, Ochi Hisaaki, Umeda Masahiro, Higuchi Toshihiro, Tanaka Chuzo
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20090418-24
• [Presentation] Magnetization transferによるMEMRIにおける造影効果の検討 (2009)
  • Author(s): 河合裕子, 梅田雅宏, 渡邉康晴, 樋口敏宏, 田中忠蔵
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-10-13
• [Presentation] cold injuryモデルにおけるMEMRIの造影効果の検討 (2009)
  • Author(s): 村瀬智一, 河合裕子, 渡邉康晴, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-10-13
• [Presentation] 拡散テンソル法によるin vivo抹消神経再生評価法の有用性 (2009)
  • Author(s): 森崎真介, 小田良, 藤原浩芳, 糸井恵, 河合裕子, 梅田雅宏, 樋口敏宏, 田中忠蔵, 久保俊一
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-10-13
• [Presentation] 塩化マンガン体内埋め込みポンプの開発 (2009)
  • Author(s): 梅田雅宏, 河合裕子, 村瀬智一, 渡邉康晴, 樋口敏宏, 田中忠蔵
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-10-13
• [Book] 磁気共鳴スペクトルの医学応用-MRSの基礎から臨床まで,第2章-2腫瘍の実験MRS (2012)
  • Author(s): 樋口敏宏
  • Total Pages: 104-111
  • Publisher: 株式会社インナービジョン