2011 Fiscal Year Final Research Report
Development of selective and efficient drug delivery system for malignant brain tumors using polymeric nanomicelles.
| Project/Area Number |
21591864
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INO Yasushi 東京大学, 医科学研究所, 准教授 (50372371)
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| Co-Investigator(Kenkyū-buntansha) |
KATAOKA Kazunori 東京大学, 大学院・工学系研究科, 教授 (00130245)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Nobuhiro 東京大学, 大学院・医学系研究科, 准教授 (10372385)
TODO Tomoki 東京大学, 医学部附属病院, 教授 (80272566)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳腫瘍学 / ドラッグデリバリーシステム |
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| Research Abstract |
We performed a basic research on the method to enhance the efficacy of polymeric nanomicelles as a drug delivery system. The polymeric nanomicelles consist of block polymers which were meticulously designed to achieve highly selective accumulation to solid tumors. The effect of co-administration of chemicals which modify permeability of tumor vasculatures, or the effect of loading tumor cell specific ligands to outer layer of the micelles were studied. A new technology for detecting in vivo distribution of the micelle was also tested.
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Research Products
(17 results)
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[Journal Article] NKX2. 2 suppresses self-renewal of glioma-initiating cells by induction of oligodendroglial differentiation2011
Author(s)
Muraguchi T, Tanaka S, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tado koro Y, Naka K, Ino Y, Todo T, KuratsuJ, Saya H, Hamada J, Hirao A.
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Journal Title
Cancer Res
Volume: Vol.71、No.3
Pages: 1135-1145
DOI
Peer Reviewed
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[Journal Article] Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells2011
Author(s)
Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H.
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Journal Title
Proc Natl Aced Sci USA.
Volume: Vol.108、No.30
Pages: 12384-12389
DOI
Peer Reviewed
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[Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009
Author(s)
Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T.
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Journal Title
Neuro-Oncolog.
Volume: Vol.11、No.2
Pages: 446-451
DOI
Peer Reviewed
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