2011 Fiscal Year Final Research Report
Overcome of resistance to therapy of maliganant gliomas by induction of autophagy
| Project/Area Number |
21591866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Yumiko 富山大学, 大学院・医学薬学研究部(医学), 教務補佐員 (30238092)
ENDO Shunro 富山大学, 大学院・医学薬学研究部(医学), 教授 (70125269)
NAGAI Shoichi 富山大学, 大学院・医学薬学研究部(医学), 助教 (20372485)
HAYASHI Nakamasa 富山大学, 大学病院, 講師 (50283073)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳腫瘍学 / 悪性グリオーマ / オートファジー / アポトーシス |
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| Research Abstract |
Malignant glioma cells are resisitant to chemothereutic agents and irradiation. The resistance to apoptosis is the main mechanism of this resistance to therapy. The second programmed cell death mechanism, autophagy is now important cell death process of malignant glioma cells. The authors investigated possibility of autophagy induction of malignant glioma cells by pharmaceutical methods. Antiapoptotic drugs and autophagy inducing drugs induced glioma cell autophagy. This strategy may be a novel therapeutic method of maliganat gliomas.
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