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2011 Fiscal Year Final Research Report

New cerebrospinal stimulation therapy using a dual-lead method

Research Project

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Project/Area Number 21591884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

YAMAMOTO Takamitsu  日本大学, 医学部, 教授 (50158284)

Co-Investigator(Kenkyū-buntansha) KATAYAMA Yoichi  日本大学, 医学部, 教授 (00125048)
FUKAYA Chikashi  日本大学, 医学部, 准教授 (50287637)
Project Period (FY) 2009 – 2011
Keywords機能脳神経外科学
Research Abstract

We have examined the usefulness of dual-lead stimulation in cerebrospinal stimulation therapy. Dual-lead cervical spinal cord stimulation(SCS) was useful for the treatment of post-stroke pain. Dual-lead stimulation of thalamic Vim/Vop and subthalamic area showed remarkable suppression of intractable tremor. Dual-lead thalamic Vc nucleus stimulation was useful for the treatment of neuropathic pain. Dual-lead Motor cortex stimulation(MCS) could be a new therapeutic approach to improving motor performance after stroke by attenuating rigidity and/or spasticity. However, it may be important to define the appropriate number of hours and conditions of daily MCS.

  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (4 results)

  • [Journal Article] DBS and SCS for vegetative state and minimally conscious state2012

    • Author(s)
      Yamamoto T, Katayama Y, Obuchi T, Kobayashi K, Oshima H, Fukaya C
    • Journal Title

      World Neurosurg

    • DOI

      DOI:10.1016/j.wneu.2012.04.010

    • Peer Reviewed
  • [Journal Article] Subthalamic nucleus stimulation for attenuation of pain related to Parkinson disease2012

    • Author(s)
      Oshima H, Katayama Y, Morishita T, Sumi K, Otaka T, Kobayashi K, Suzuki Y, Fukaya C, Yamamoto T
    • Journal Title

      J Neurosurg

      Volume: 116(1) Pages: 99-106

    • DOI

      DOI:10.3171/2011.7.JNS11158

    • Peer Reviewed
  • [Journal Article] Changes in motor function induced by chronic motor cortex stimulation in post-stroke pain patients2011

    • Author(s)
      Yamamoto T, Katayama Y, Watanabe M, Sumi K, Obuchi T, Kobayashi K, Oshima H, Fukaya C
    • Journal Title

      Stereotact Funct Neurosurg

      Volume: 89(6) Pages: 381-389

    • DOI

      DOI:10.1159/000332060

    • Peer Reviewed
  • [Journal Article] Corticospinal descending direct wave elicited by subcortical stimulation2011

    • Author(s)
      Fukaya C, Sumi K, Otaka T, Shijo K, Nagaoka T, Kobayashi K, Oshima H, Watanabe T, Yamamoto T, Katayama Y
    • Journal Title

      J Clin Neurophysiol

      Volume: 28(3) Pages: 297-301

    • DOI

      DOI:10.1097/WNP.0b013e31821c2fc3

    • Peer Reviewed
  • [Journal Article] Deep brain stimulation for the treatment of vegetative state2010

    • Author(s)
      Yamamoto T, Katayama Y, Kobayashi K, Oshima H, Fukaya C, Tsubokawa T
    • Journal Title

      Eur J Neurosci

      Volume: 32(7) Pages: 1145-1151

    • DOI

      DOI:10.1111/j.1460-9568.2010.07412.x

    • Peer Reviewed
  • [Journal Article] Thalamic deep brain stimulation for the treatment of action myoclonus caused by perinatal anoxia2010

    • Author(s)
      Kobayashi K, Katayama Y, Otaka T, Obuchi T, Kano T, Nagaoka T, Kasai M, Oshima H, Fukaya C, Yamamoto T
    • Journal Title

      Stereotact Funct Neurosurg

      Volume: 88(4) Pages: 259-263

    • DOI

      DOI:10.1159/000315464

    • Peer Reviewed
  • [Journal Article] Nexframe frameless stereotaxy with multitract microrecording : accuracy evaluated by frame-based stereotactic X-ray2010

    • Author(s)
      Fukaya C, Katayama Y, Sumi K, Otaka T, Obuchi T, Kano T, Nagaoka T, Oshima H, Yamamoto T
    • Journal Title

      Stereotact Funct Neurosurg

      Volume: 88(3) Pages: 163-168

    • DOI

      DOI:10.1159/000313868

    • Peer Reviewed
  • [Journal Article] Effects of electrode implantation angle on thalamic stimulation for treatment of tremor2010

    • Author(s)
      Kobayashi K, Katayama Y, Sumi K, Obuchi T, Kano T, Nagaoka T, Oshima H, Fukaya C, Yamamoto T, Atsumi H
    • Journal Title

      Neuromodulation

      Volume: 13(1) Pages: 31-36

    • DOI

      doi:10.1111/j.1525-1403.2009.00235.x

    • Peer Reviewed
  • [Presentation] DBS for traumatic and vascular brain injury2011

    • Author(s)
      Yamamoto T, Fukaya C, Katayama Y
    • Organizer
      10^<th> International Neuromodulation Society
    • Place of Presentation
      London
    • Year and Date
      20110000
  • [Presentation] Mapping of primary motor and premotor cortex.(keynote lecture)2011

    • Author(s)
      Yamamoto T, Obuchi T, Kano T, Kobayashi K, Oshima H, Fukaya C, Katayama Y
    • Organizer
      3rs International Society of Intraoperative Neurophysiology
    • Place of Presentation
      Barcelona
    • Year and Date
      2011-09-08
  • [Presentation] Cerebrospinal stimulation and low-dose ketamine drip infusion therapy for the treatment of neuropathic pain2010

    • Author(s)
      Yamamoto T, Kobayashi K, Oshima H, Fukaya C, Katayama Y
    • Organizer
      ISRN Interim Meeting
    • Place of Presentation
      St. Petersburg
    • Year and Date
      2010-01-07
  • [Presentation] Dual-lead SCS combined with low-dose ketamine drip infusin therapy for the treatment of neuropathic pain2009

    • Author(s)
      Yamamoto T, Obuchi T, Kano T, Oshima H, Fukaya C, Katayama Y
    • Organizer
      7^<th> Congress of Asian Australesian Stereotactic and Functional Neurosurgery
    • Place of Presentation
      Hong-Kong
    • Year and Date
      20090000
  • [Presentation] Cerebrospinal stimulation therapy for the treatment of VS and MCS2009

    • Author(s)
      Yamamoto T, Fukaya C, Katayama Y
    • Organizer
      XIV World Federation of Neurosurgical Society
    • Place of Presentation
      Boston
    • Year and Date
      20090000
  • [Presentation] Intraoprative neurophysiology in glioma surgery and functional neurosurgery2009

    • Author(s)
      Yamamoto T, Fukaya C, Katayama Y
    • Organizer
      2nd International Conference of Intraoperative Neurophysiology
    • Place of Presentation
      Dobrovnik
    • Year and Date
      20090000
  • [Book] ニューロモデユレーションに用いる脳脊髄刺激装置:わが国での始まりと進歩、ニューロモデユレーション技術の進展と疼痛治療への応用2012

    • Author(s)
      山本隆充, 小林一太、大島秀規、深谷親, 片山容一
    • Total Pages
      S3-S11
    • Publisher
      真興交易医書出版部
  • [Book] 大脳皮質運動野刺激による疼痛治療の実際(電気刺激療法)、ニューロモデユレーション技術の進展と疼痛治療への応用2012

    • Author(s)
      山本隆充, 小林一太、大島秀規、深谷親, 片山容一
    • Total Pages
      S113-S120
    • Publisher
      真興交易医書出版部
  • [Book] 脳卒中後疼痛、神経障害性疼痛2011

    • Author(s)
      山本隆充、片山容一
    • Total Pages
      173-179
    • Publisher
      克誠堂出版
  • [Book] 神経障害性疼痛の治療:中枢性疼痛に対する低用量ケタミン点滴療法、ペインクリニック別冊春号2009

    • Author(s)
      山本隆充、深谷親、大渕敏樹、片山容一
    • Total Pages
      183-188

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Published: 2013-07-31  

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