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2011 Fiscal Year Final Research Report

Establishment of a Novel Therapeutic Strategy Using Tissue Regeneration for Intractable Spinal Infections.

Research Project

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Project/Area Number 21591889
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

ITO Manabu  北海道大学, 大学院・医学研究科, 特任教授 (00271677)

Co-Investigator(Kenkyū-buntansha) AKAZAWA Toshiyuki  地方独立行政法人北海道立総合研究機構, 産業技術研究本部 工業試験場高分子・セラミックス材料グループ, 研究主幹 (80469692)
HOJYO Yoshihiro  北海道大学, 大学院・医学研究科, 助教 (60451423)
Project Period (FY) 2009 – 2011
Keywordsリン酸カルシウム / 超音波処理 / 抗生物質 / 骨形成蛋白質 / 吸着徐放性 / 脊椎感染症
Research Abstract

Commercial porous bioceramics were partially dissolved in saturated acid solutions and calcium phosphate microcrystals were precipitated on the surfaces of bioceramics by the supersonic dissolution -precipitation method. Calcium phosphate ceramics having excellent bio-absorption and osteoinduction were newly produced by controlling adsorption and release characteristics of bone-morphogenetic protein (rhBMP-2). As a surface modification technique of bioceramics, the supersonic treatment technology using commercial parenteral fluids was established and antibiotic (Cefazolin)-adsorption and release characteristics on the ceramics were clarified. Biomimetic composites of apatite and collagen which were suitable for tissue regeneration were synthesized and the good bio-absorption was recognized. Concerning a quantitative evaluation for patients with intractable spinal infections, severity maps of infection sites were created in 8 cases of intractable spinal infections by using FDG-PET CT.

  • Research Products

    (35 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 12 results) Presentation (17 results) Book (1 results)

  • [Journal Article] Characterization of bio-absorbable and biomimetic apatite/collagen composite powders derived from fish bone and skin by the dissolution-precipitation method2012

    • Author(s)
      T Akazawa, M Murata, M Ito, et al.
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 114-119

    • DOI

      DOI:10.4028/www.scientific.net/KEM.493-494.114

    • Peer Reviewed
  • [Journal Article] 腰椎感染性病変に対する内視鏡手術2012

    • Author(s)
      伊東学
    • Journal Title

      MB Orthop

      Volume: 25巻 Pages: 54-60

  • [Journal Article] 脊椎感染症と腰痛2012

    • Author(s)
      長濱賢, 伊東学
    • Journal Title

      第6章脊椎各要素と腰痛(1)椎体.脊椎脊髄

      Volume: 25巻 Pages: 281-287

  • [Journal Article] Improved Bioabsorbability of Synthetic Hydroxyapatite through Partial dissolution-precipitation of its Surface2011

    • Author(s)
      X Ding, M Takahata, T Akazawa, N Iwasaki, Y Abe, M Komatsu, M Murata, M Ito, et al.
    • Journal Title

      J Mater Sci : Mater Med

      Volume: 22巻 Pages: 1247-1255

    • DOI

      DOI:10.1007/s10856-011-4291-x

    • Peer Reviewed
  • [Journal Article] Microstructure and Biocompatibility of Hydroxyapatite Porous Ceramics Designed by a Partial Dissolution-Precipitation Technique with Supersonic Treatment for Bone Regeneration2011

    • Author(s)
      T Akazawa, M Murata, Y Tabata, M Ito
    • Journal Title

      Bone Regeneration

    • Peer Reviewed
  • [Journal Article] Retrospective Multicenter Study of Surgical Treatments for Osteoporotic Vertebral Fractures2010

    • Author(s)
      M Ito, et al.
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 15巻 Pages: 289-293

    • Peer Reviewed
  • [Journal Article] Characterization of microstructure and bio-absorption of hydroxyapatite ceramics modified by a partial dissolution and precipitation technique using supersonic treatment2010

    • Author(s)
      T Akazawa, M Murata, M Takahata X Ding, Y Abe, K Nakamura, J Hino, J Tazaki, K Ito, M Ito, et al.
    • Journal Title

      Journal of Ceramic Society of Japan

      Volume: 118巻 Pages: 535-540

    • Peer Reviewed
  • [Journal Article] Penetration of linezolid into rabbit intervertebral discs and surrounding tissues2010

    • Author(s)
      M Komatsu, M Takahata, M Sugawara, Y Takekuma, T Kato, M Ito, et al.
    • Journal Title

      European Spine Journal

      Volume: 19巻 Pages: 2149-2155

    • Peer Reviewed
  • [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurological deficits2010

    • Author(s)
      H Sudo, M Ito, et al.
    • Journal Title

      European Spine Journal

      Volume: 19巻 Pages: 907-915

    • Peer Reviewed
  • [Journal Article] Bone induction of human tooth and bone crushed by newly developed automatic mill2010

    • Author(s)
      M Murata, T Akazawa, M Takahama, M Ito, et al
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118巻 Pages: 434-437

    • Peer Reviewed
  • [Journal Article] Simultaneous Double Rod Rotation Technique in Posterior Instrumentation Surgery for Correction of Adolescent Idiopathic Scoliosis2010

    • Author(s)
      M Ito, et al.
    • Journal Title

      J of Neurosurgery : Spine

      Volume: 12巻 Pages: 93-300

    • Peer Reviewed
  • [Journal Article] 脊椎外科における生体内吸収性材料使用の可能性2010

    • Author(s)
      放生憲博, 伊東学, ほか
    • Journal Title

      脊椎脊髄

      Volume: 23巻 Pages: 59-65

  • [Journal Article] 化膿性脊椎炎に対する経皮的鏡視下病巣掻爬洗浄術2010

    • Author(s)
      伊東学
    • Journal Title

      The Spine Perspective

      Volume: 7巻 Pages: 11-14

  • [Journal Article] 脊柱再建術における生体材料の歴史的展開-ショートレビュ-2010

    • Author(s)
      伊東学
    • Journal Title

      脊椎脊髄

      Volume: 23巻 Pages: 16-18

  • [Journal Article] Minimally invasive surgical treatment for tuberculous spondylodiscits2009

    • Author(s)
      M Ito, et al.
    • Journal Title

      Minimally Invasive Neurosurgery

      Volume: 52巻 Pages: 250-253

    • Peer Reviewed
  • [Journal Article] Microstructure and Bio-Absorption Characteristics of Hydroxyapatite Modified by a Partially Supersonic Dissolution-Precipitation Technique2009

    • Author(s)
      T Akazawa, M Murata, M Takahama, D Xianjun, Y Abe, K Nakamura, J Hino, J Tazaki, K Ito, M Ito, et al.
    • Journal Title

      Archives of BioCeramics Research

      Volume: 9巻 Pages: 123-126

    • Peer Reviewed
  • [Journal Article] 生体模倣性アパタイトの開発と骨再生工学2009

    • Author(s)
      赤澤敏之, 村田勝, 伊東学
    • Journal Title

      Phosphorus Letter

      Volume: 66巻 Pages: 4-13

    • Peer Reviewed
  • [Presentation] Posterolateral endoscopic debridement and irrigation for postoperative spinal infections in the thoraco-lumbar spine2012

    • Author(s)
      K Nagahama, M Ito, et al.
    • Organizer
      12th Annual Conference of International Society for the Advancement of Spine Surgery
    • Place of Presentation
      Spain
    • Year and Date
      20120302-23
  • [Presentation] Characterization of bio-absorbable and biomimetic apatite/collagen composite powders derived from fish bone and skin by the dissolution-precipitation method2011

    • Author(s)
      T Akazawa, M Ito et al.
    • Organizer
      Bioceramics 23
    • Place of Presentation
      Turkey
    • Year and Date
      20111106-09
  • [Presentation] Minimally invasive surgery for spinal infection2011

    • Author(s)
      M Ito
    • Organizer
      AO spine advances course
    • Place of Presentation
      Yokohama Symposia, Kanagawa
    • Year and Date
      20110929-1001
  • [Presentation] 水酸アパタイト顆粒の表面設計とその抗生物質吸着特性2011

    • Author(s)
      赤澤敏之,伊東学, 他
    • Organizer
      日本セラミックス協会秋季シンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20110907-09
  • [Presentation] 脊椎外科領域におけるバイオマテリアルの現状と将来2011

    • Author(s)
      伊東学
    • Organizer
      日本セラミックス協会秋季シンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20110907-09
  • [Presentation] Evidence of effectiveness of MIS treatment for spinal infections in thoracic to lumbosacral spine2011

    • Author(s)
      M Ito
    • Organizer
      15th International ArgoSpine Symposium
    • Place of Presentation
      France
    • Year and Date
      20110127-18
  • [Presentation] Evidence of effectiveness of MIS treatment for spinal infections in thoracic to lumbosacral spine2011

    • Author(s)
      M Ito
    • Organizer
      15th Argospine Symposium
    • Place of Presentation
      Pullman Paris Tour Eiffel, Paris, French
    • Year and Date
      20110127-18
  • [Presentation] 脊椎感染症の最近の動向と治療最前線2011

    • Author(s)
      伊東学
    • Organizer
      長崎LCSフォーラム
    • Place of Presentation
      ホテルニュー長崎(長崎県)
    • Year and Date
      2011-11-17
  • [Presentation] The role of minimally invasive surgery for treatment of spinal infections, 2011 Annual Meeting of Taiwan Spine Society2011

    • Author(s)
      M Ito
    • Organizer
      19th Annual Congress of Taiwan of Taiwan Spine Society
    • Place of Presentation
      Chang Gung Memorial Hospital, Taipei, Taiwan
    • Year and Date
      2011-03-19
  • [Presentation] Effectiveness of posterolateral endoscopic debridement and irrigation for various types of spinal infection at thoracic and lumbar spine2010

    • Author(s)
      M Ito
    • Organizer
      The 5^<th> Sino-Japan Symposium on Spine Infections
    • Place of Presentation
      HJ International Hotel, Dongguan, China
    • Year and Date
      20101202-04
  • [Presentation] Minimally invasive surgery for spinal infection2010

    • Author(s)
      M Ito
    • Organizer
      AO spine advances course
    • Place of Presentation
      Yokohama Symposia, Yokohama, Japan
    • Year and Date
      20100930-1002
  • [Presentation] Effectiveness of Posterolateral Endoscopic Debridement and Irrigation for Various Types of Spinal Infection at Thoracic andLumbar Spine2010

    • Author(s)
      M Ito, et al.
    • Organizer
      7th SICOT/SIROT Annual International Conference combined with Swedish Orthopaedic Association
    • Place of Presentation
      Swedish Exhibition and Congress Centre, Gothenburg, Sweden
    • Year and Date
      20100830-0903
  • [Presentation] Infectious spondylodiscitis treated by endoscopic debridement2010

    • Author(s)
      M Ito
    • Organizer
      2^<nd> World Cogress of Minimally Invasive Spine Surgery and Techniques
    • Place of Presentation
      The MGM Grand Hotel, as Vegas, USA
    • Year and Date
      20100531-0604
  • [Presentation] Percutaneous endoscopic procedure for spinal infections2010

    • Author(s)
      M Ito
    • Organizer
      The 2^<nd> MISS Summit Forum
    • Place of Presentation
      Aichi Spine Center, Aichi
    • Year and Date
      2010-03-13
  • [Presentation] MIS for discitis and spondylitis2009

    • Author(s)
      M Ito
    • Organizer
      AO Spine Advanced Course
    • Place of Presentation
      Yokohama Symposia, Yokohama
    • Year and Date
      2009-09-17
  • [Presentation] 臨床現場が金属材料に求める生体機能の即時代替と生体適合性の向上2009

    • Author(s)
      伊東学
    • Organizer
      日本金属学会2009年秋季大会
    • Place of Presentation
      京都大学,京都
    • Year and Date
      2009-09-15
  • [Presentation] 高齢化社会における硬組織再生・再建の重要性2009

    • Author(s)
      伊東学
    • Organizer
      第18回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      北海道医療大学札幌キャンパス,札幌
    • Year and Date
      2009-09-05
  • [Book] 膿性脊椎炎2011

    • Author(s)
      伊東学
    • Total Pages
      140-147
    • Publisher
      中山書店

URL: 

Published: 2013-07-31  

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