Patho-mechanism of discogenic low back pain

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: TAKAHASHI Kazuhisa 千葉大学, 大学院・医学研究院, 教授 (20179477)
• Co-Investigator(Kenkyū-buntansha): OTORI Seiji 千葉大学, 大学院・医学研究院, 助教 (40361430)
• Project Period (FY): 2009 – 2011
• Keywords: 椎間板 / 腰痛 / 細胞内シグナル / サイトカイン

Research Abstract

SUMMARY OF BACKGROUND DATA : BDNF-a neurotrophin in DRG neurons-is anterogradely transported to the spinal cord and transmits pain signals. Its presence in the peripheral sites of degenerative IVDs has been recently reported, although its association with discogenic pain remains unclear. Direct intradiscal application of the anti-BDNF antibody significantly suppressed both CGRP production and the local concentration of BDNF. Our results indicate a possible association between the local production of BDNF and the pathophysiology of discogenic pain.

Research Products

• [Journal Article] Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats (2011)
  • Author(s): Orita S, Eguchi Y, Kamoda H, Arai G, Ishikawa T, Miyagi M, Inoue G, Suzuki M, Toyone T, Aoki Y, Takahashi K, Ohtori S
  • Journal Title: Spine (Phila Pa1976) Volume: 36(21) Pages: 1737-43
  • Peer Reviewed
• [Journal Article] Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons (2011)
  • Author(s): Horii M, Orita S, Nagata M, Takaso M, Yamauchi K, Yamashita M, Inoue G, Eguchi Y, Ochiai N, Kishida S, Aoki Y, Ishikawa T, Arai G, Miyagi M, Kamoda H, Kuniyoshi K, Suzuki M, Nakamura J, Toyone T, Takahashi K, Ohtori S
  • Journal Title: Spine Volume: 36 Pages: E80-5
  • Peer Reviewed
• [Journal Article] Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model (2010)
  • Author(s): Fukui Y, Ohtori S, Yamashita M, Yamauchi K, Inoue G, Suzuki M, Orita S, Eguchi Y, Ochiai N, Kishida S, Takaso M, Wakai K, Hayashi Y, Aoki Y, Takahashi K
  • Journal Title: J Orthop Res Volume: 28 Pages: 279-83
  • Peer Reviewed