2011 Fiscal Year Final Research Report
Selective induction and transplantation of iPS cell-derived astrocytes into acute spinal cord injury
| Project/Area Number |
21591892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
MURATA Atsushi 千葉大学, 医学部・附属病院, 准教授 (20344997)
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| Co-Investigator(Kenkyū-buntansha) |
OKAWA Akihiko 千葉大学, 医学部附属病院, 講師 (30312945)
YAMAZAKI Masashi 千葉大学, 大学院・医学研究院, 准教授 (50281712)
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| Project Period (FY) |
2009 – 2011
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| Keywords | iPS細胞 / 脊髄損傷 / Neural Stem Sphere法(NSS法) / アストロサイト / アロディニア / BBBスコア |
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| Research Abstract |
We transplanted iPS cell-derived astrocytes into rat spinal cords three and seven days after spinal cord contusion injury. BBB locomotor recovery did not show statistically significant change in both transplantations. Although transplanted cells were survived eight weeks after transplantation, they did not show immunoreactivity for GFAP. There was no statistical significant histological finding. Although transplanted astrocytes has relation to induce allodynia, it depends on the timing of transplantation.
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