2011 Fiscal Year Final Research Report

Positive Effect on Bone Fusion by the Combination of Platelet-Rich Plasma and a Gelatinβ-Tricalcium Phosphate Sponge : A Study Using a Posterolateral Fusion Model of Lumbar Vertebrae in Rats

Research Project

Project/Area Number	21591903
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	HASE Hitoshi 京都府立医科大学, 医学研究科, 准教授 (00172883)
Co-Investigator(Kenkyū-buntansha)	MIKAMI Yasuo 京都府立医科大学, 医学研究科, 講師 (80360030) IKEDA Takumi 京都府立医科大学, 医学研究科, 助教 (40453120)
Research Collaborator	OKAMOTO Shinichi 京都府立医科大学, 医学研究科, 大学院生
Project Period (FY)	2009 – 2011
Keywords	多血小板血漿 / ゼラチンβ-TCPスポンジ / 脊椎固定術
Research Abstract	The positive effect on bone fusion using the combination of PRP and the gelatinβ-TCP sponge is equivalent to that of autogenous bone grafting. This method might be less invasive than autogenous bone grafting in terms of being able to induce bone fusion by autologous blood without impairing of healthy donor site. This method also has the advantage of being very safe to perform, because all these materials have already been extensively used clinically. The current study demonstrates that the bone fusion method using the combination of PRP and the gelatinβ-TCP sponge could be an alternative to autogenous bone grafting in terms of its effectiveness, lower invasiveness, and safety.

(2 results)