2011 Fiscal Year Final Research Report
A study of injectable osteoconductive bone substitute materials
| Project/Area Number |
21591910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
IMAIZUMI Hideki 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70250785)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948)
ITOI Eiji 東北大学, 大学院・医学系研究科, 教授 (80193465)
KISHIMOTO Koushi 東北大学, 病院, 助教 (10344665)
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| Co-Investigator(Renkei-kenkyūsha) |
ANADA Takahisa 東北大学, 大学院・歯学研究科, 助教 (30398466)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リン酸カルシウム / ヒアルロン酸 |
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| Research Abstract |
Octacalcium phosphate(OCP)crystals, having particular stoichiometeric composition, have been shown to display a stimulatory capacity on osteoblastic differentiation and bone regeneration. Synthesized OCP crystals show higher biocompatibility and are expected to be an artificial bioabsorbable material. On the other hand, its brittleness based on the ceramics characteristics makes it difficult to mold the objective shape. In the present study, we created a new OCP materials combined with hyaluronan(Hya), which could be used as the injectable form, and examined their bone regenerative properties on mouse calvaria.
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