2011 Fiscal Year Final Research Report
Magnetic targeting therapy with new bisphosphonates for the treatment of bone metastasis
| Project/Area Number |
21591916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OCHI Mitsuo 広島大学, 大学院・医歯薬学総合研究科, 教授 (70177244)
SHIMOSE Shouji 広島大学, 大学院・医歯薬学総合研究科, 准教授 (30304439)
MATSUO Toshihiro 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師 (90397977)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 |
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| Research Abstract |
Bisphosphonates, widely used to treat a variety of bone resorption diseases, reportedly have some antitumor effects. In this study, we developed novel bisphosphonates for cancer immunotherapy for bone metastasis and, more, Vanadium/ bisphosphonate complex for the treatment of malignant bone tumors.
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[Journal Article] Lipophilic bisphosphonates as dualfarnesyl/ geranylgeranyl diphosphate synthase inhibitors : an X-ray and NMRinvestigation2009
Author(s)
Zhang Y, Cao R, Yin F, Hudock MP, GuoRT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, LeonA, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, KuboT, Ochi M, Mukkamala D, Oldfield E.
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Journal Title
J Am Chem Soc
Volume: 131(14)
Pages: 5153-62
Peer Reviewed
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