2011 Fiscal Year Final Research Report
Molecular target therapy for muscloskeletal sarcoma-initiating cells
| Project/Area Number |
21591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
SETOGUCHI Takao 鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (40423727)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANO Satoshi 鹿児島大学, 大学院・医歯学総合研究科, 助教 (50373139)
KOMIYA Setsuro 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30178371)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨肉腫 / 横紋筋肉腫 / 腫瘍幹細胞 / Hedgehog, Sarcoma-initiating cell |
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| Research Abstract |
Rhabdomyosarcoma cell lines included small populations of fibroblast growth factor receptor 3(FGFR3)-positive cells. FGFR3-positive KYM-1 and RD cells were more strongly tumourigenic than FGFR3-negative cells. Our findings suggest that rhabdomyosarcoma cell lines include a minor subpopulation of FGFR3-positive sarcoma-initiating cells, which can be maintained indefinitely in culture and which is crucial for their malignancy. In addition, We found that inhibition of Hedgehog pathway prevents osteosarcoma and rhabdomyosarcoma growth. Our findings suggest that inhibition of Hedgehog pathway may represent an effective therapeutic approach for patients with osteosarcoma and rhabdomyosarcoma.
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