2011 Fiscal Year Final Research Report
Novel Strategy of Gene Therapy for Musculoskeletal Sarcoma-Targeting Intratumoral Spread of Viral Vectors
| Project/Area Number |
21591920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGANO Satoshi 鹿児島大学, 医歯学総合研究科, 助教 (50373139)
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| Co-Investigator(Kenkyū-buntansha) |
KOMIYA Setsuro 鹿児島大学, 医歯学総合研究科, 教授 (30178371)
SETOGUCHI Takao 鹿児島大学, 医歯学総合研究科, 特任准教授 (40423727)
KAMIZONO Junichi 鹿児島大学, 医学部歯学部付病院, 医員 (30444897)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 遺伝子治療 / ウイルスベクター / 骨軟部腫瘍 |
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| Research Abstract |
We generated a novel survivin-responsive Surv. m-CRA-OCp, which is regulated by the survivin promoter and cancer/tissue-specific osteocalcin promoter, and demonstrated reduced toxicity to normal tissues, while maintaining its anticancer effects. Significant contribution of matrix-metalloproteinase-14 on vascular invasion and metastasis of breast cancer is shown. We analyzed hedgehog pathway in osteosarcoma and showed that inhibition of GLI2 may represent an effective therapeutic approach for patients with osteosarcoma.
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