2011 Fiscal Year Final Research Report
Abnormal DNA double-strand break repair in human malignant soft tissue tumors
| Project/Area Number |
21591926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | 独立行政法人国立病院機構九州がんセンター臨床研究センター (2011)
Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center (2009-2010) |
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Principal Investigator |
TANAKA Kazuhiro 独立行政法人国立病院機構九州がんセンター臨床研究センター, 臨床研究センター (10274458)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨・軟部腫瘍学 / 発がん / 染色体転座 / DNA二本鎖切断修復 |
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| Research Abstract |
Chromosomal translocations to generate chimaeric fusion genes are a hallmark of a group of soft tissue sarcomas. Whereas the pathogenic significance of these anomalous genes has been generally established in tumours of this category, the origin of gene fusion still remains unknown. Using DNA microarrays, we observed expression of the genes participating in the DNA double-strand break repair pathways. In two cell lines established from human Ewing's sarcomas, their expression was uniformly elevated. Aberrant expression of double-strand break repair genes may be generally associated with tumourigenesis by the chimaeric fusion genes.
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