Clarifying the role of IKK. NFκB signaling axis in bone formation using lineage specific conditional knockout mice.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: KATO Tomohisa 京都大学, 再生医科学研究所, 講師 (50301247)
• Co-Investigator(Kenkyū-buntansha): TOGUCHIDA Junya 京都大学, 再生医科学研究所, 教授 (40273502)
• Project Period (FY): 2009 – 2011
• Keywords: 造骨機構 / 細胞系譜 / シグナル伝達 / NF-κB / IKK

Research Abstract

Using osteoblastic cell lineage-specific and chondrocyte specific conditional knockout mice, we have investigated the role of IKK. NF-κB signaling axis in cells that contribute to bone formation. We found that Ikkβplays role in mesenchymal cells of limb bud in early development. Those cells deregulated the chondrocytes in growth plate of the long bone of post natal mice.

Research Products

• [Journal Article] Nuclear IKK(R) is an adaptor protein for I. Bαubiquitination and degradation in UV-induced NF-B activation (2012)
  • Author(s): Tsuchiya, Y., Asano, T., Nakayama, K., Kato, Jr., T., Karin, M. and Kamata, H.
  • Journal Title: Molecular Cell Volume: 39 Pages: 570-582
  • DOI: DOI:10.1016/j.molcel.
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase (2010)
  • Author(s): Jin, Y., Kato, T., Furu, M., Nasu, A., Kajita, Y., Mitsui, H., Ueda, M., Aoyama, T., Nakayama, T., Nakamura, T. and Toguchida, J.
  • Journal Title: Biochem Biophys Res Commun Volume: 391 Pages: 1471-1476
  • DOI: DOI:10.1016/j.bbrc
  • Peer Reviewed