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2012 Fiscal Year Final Research Report

Investigation of new relations between neural and skeletal tissues

Research Project

  • PDF
Project/Area Number 21591943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

HIGUCHI Chikahisa  大阪大学, 保健センター, 助教 (40432421)

Co-Investigator(Renkei-kenkyūsha) TANAKA Hiroyuki  大阪大学, 大学院・医学系研究科, 助教 (00432542)
Project Period (FY) 2009 – 2012
Keywords骨芽細胞分化 / Netrin / Unc5 / 神経組織 / Schwannoma / Noggin / Mek5-Erk5
Research Abstract

In order to explore new relations between neurological tissue and skeletal tissue, we investigated functions of Netrin-1, which is one of neural axon extension molecules, on osteoblasts. Moreover, we searched out a bone-formation inhibitory protein secreted by neuronal tumor. We demonstrated that Netrin-1 have inhibitory effects of osteoblastic differentiation without proliferative suppression. In addition, we identified one of bone-formation inhibitory factors, Noggin, secreted by neuronal tissues. On the other hand, MEK5-Erk5 signal transduction pathway exists in osteoblasts and it suppresses osteoblastic differentiation.

  • Research Products

    (3 results)

All 2011

All Presentation (3 results)

  • [Presentation] Netrin-1 suppresses osteoblastic differentiation.2011

    • Author(s)
      金子恵子、 樋口周久、吉田清志、吉川秀樹
    • Organizer
      第25回 SICOT(Societe Internationale de Chirurgie Orthopedique et de Traumatologie) Triennial World Congress
    • Place of Presentation
      プラハ・チェコ共和国
    • Year and Date
      20110906-09
  • [Presentation] Netrin-1 の骨芽細胞分化に対する影響2011

    • Author(s)
      金子恵子、 樋口周久、吉田清志、吉川秀樹
    • Organizer
      第26回日本整形外科基礎学術集会
    • Place of Presentation
      前橋市
    • Year and Date
      2011-10-20
  • [Presentation] Netrin-1 の骨芽細胞分化に対する影響2011

    • Author(s)
      金子恵子、 樋口周久、吉田清志、吉川秀樹
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-07-28

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Published: 2014-08-29  

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