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2011 Fiscal Year Final Research Report

The anti-inflammatory effects of stat in on osteoarthritis

Research Project

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Project/Area Number 21591949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

MATSUDA Shuichi  九州大学, 医学研究院, 准教授 (40294938)

Project Period (FY) 2009 – 2011
Keywords変形性関節症 / 関節軟骨 / スタチン
Research Abstract

Thirty-two mature rabbits that underwent bilateral anterior cruciate ligament transaction(ACLT) received six consecutive weekly intra-articular injections of mevastatin. The knee joints were assessed by morphological, histological and biochemical methods.
Intra-articular injection of mevastatin significantly reduced cartilage degradation, as assessed by morphological and histological examinations. During the development of experimental OA, intra-articular administration of statin reduces cartilage degradation.

  • Research Products

    (10 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Displacement of the Tibia Increases in Deep Flexion of the Knee Joint2010

    • Author(s)
      Fukagawa S, Matsuda S, Tashiro Y, Hashizume M, Iwamoto Y. Posterior
    • Journal Title

      Crin Orthop

      Volume: 468 Pages: 1107-1114

    • Peer Reviewed
  • [Journal Article] Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammatio2009

    • Author(s)
      Akasaki Y, Matsuda S, Nakayama K, Miura H, Fukagawa S, Iwamoto Y.
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 17 Pages: 235-243

    • Peer Reviewed
  • [Journal Article] Agerelated changes in kinematics of the knee joint during deep squat

    • Author(s)
      Fukagawa S, Leardini A, Callewart B, Wong PD, Desloovere K, Matsuda S, Bellemans J.
    • Journal Title

      The Knee

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Articular cartilage of the posterior condyle can affect rotational alignment in total knee arthroplasty

    • Author(s)
      Tashiro Y, Uemura M, Matsuda S, Okazaki K, Kawahra S, Hashizume M, Iwamoto Y.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc. Ip L)

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Inhibition of geranylgeranylation reduces MCP-l production in IL-lis-stimulated human synoviocytes2012

    • Author(s)
      Akasaki Y, Matsuda S, Kawahara S, Iwamoto Y.
    • Organizer
      Orthopedic Research Society 2012
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-02-04
  • [Presentation] 変形性膝関節症における最近のトピックス(招待講演)2011

    • Author(s)
      松田秀一
    • Organizer
      福岡労災保険指定病院協会学術講i演会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-05-24
  • [Presentation] ADRCを用いた骨軟骨再生(招待講演)2011

    • Author(s)
      中山功一、松田秀一、他
    • Organizer
      第24回軟骨代謝学会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-03-05
  • [Presentation] ll-lβ刺激滑膜細胞において、スタチンはイソプレノイドの合成を阻害することでMCP-lとMMP-sの産生を抑制する2011

    • Author(s)
      川原慎也、松田秀一、他
    • Organizer
      第24回軟骨代謝学会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-03-04
  • [Presentation] 変形性膝関節症治療のup-to-date(招待講演)2010

    • Author(s)
      松田秀一
    • Organizer
      第67回DOC研究
    • Place of Presentation
      福岡市
    • Year and Date
      2010-09-02
  • [Presentation] Statins prevent production of monocyte chemoattractant protein-l and matrixmetalloproteinase-s in IL-I stimulated synoviocytes through inhibition of protein isoprenylation2009

    • Author(s)
      Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Miura H, Iwamoto Y.
    • Organizer
      The 55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      20090222-25

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Published: 2013-07-31  

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