2011 Fiscal Year Final Research Report
From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.
| Project/Area Number |
21591951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAOKA Masashi 大分大学, 医学部, 准教授 (40301379)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オステオポンチン / 骨粗鬆症 / トランスジェニックマウス / 遺伝子改変マウス |
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| Research Abstract |
We generated transgenic(OPN-TG) mice expressing osteopontin(OPN) which is a phosphoglycoprotein secreted by osteoblasts mainly. We found that an increase of calcium and type I collagen cross linked N teropeptide(NTx) in serum of OPN-TG mice, compared with normal mice. OPN-TG mice showed a decrease of bone density obtained by QCT and so is a useful model of human osteoporosis. Furthermore, we need in vitro analysis of the bone marrow cells with OPN-related proteins or peptides.
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Research Products
(1 results)
