2011 Fiscal Year Final Research Report
The role of interleukin-32 on inflammatory arthritis and the possibility of being a therapeutic target.
| Project/Area Number |
21591959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
NIKI Yasuo 慶應義塾大学, 医学部, 講師 (10276298)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Masanori 慶應義塾大学, 医学部, 助教 (70528249)
KAWASAI Toshiki 慶應義塾大学, 医学部, 助教 (30365291)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リウマチ病学 / 炎症性サイトカイン |
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| Research Abstract |
IL-32 induces TNF. via NF. B and ERK signaling pathway and contributes to developing inflammatory arthritis through loss of proteoglycan and provocation of synovitis. Since IL-32 induced TNF. had gradually reduced and IL-10 had gradually increased, IL-32 might develop inflammation in early stage and resolve subsequently.
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