2011 Fiscal Year Final Research Report
Importance of tailor-made treatment for primary osteoporosis : Evaluation based on measurements of bone density and bone quality.
| Project/Area Number |
21591962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
SAITO Mitsuru 東京慈恵会医科大学, 医学部, 准教授 (50301528)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIZAWA Tetsuro 東京慈恵会医科大学, 医学部, 助教 (50439791)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 原発性骨粗鬆症 / 骨質 / 骨密度 / 動物モデル / テーラーメード治療 |
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| Research Abstract |
Biochemical markers of bone quality following administration of different pharmacological agents were measured in a rabbit hyperhomocysteinemia model(an experimental model of reduced human bone quality) developed in our laboratory. The results clearly indicated, similarly to our previously reported findings on human reduced-bone-quality-type osteoporosis that by incurring direct detrimental changes on collagen coss-links homocysteine reduces bone strength ; this mechanism is independent of reduction in bone density.
Additionally, based on findings that estrogen receptor modulators are more effective in patients with reduced-bone-quality-type osteoporosis, we suggest subdividing patients accordingly with the type of osteoporosis upon diagnosis and treatment of the disease.
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