2011 Fiscal Year Final Research Report
Molecular basis clarification for pain and stress reaction in injury and arthritis of transgenic animals.
| Project/Area Number |
21591964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
OHNISHI Hideo 産業医科大学, 医学部, 講師 (20279342)
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| Co-Investigator(Kenkyū-buntansha) |
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛ストレス / 遺伝子改変動物 / 前初期遺伝子 / 赤色蛍光タンパク / 視床下部室傍核 / 脊髄後角 |
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| Research Abstract |
The purpose of the study was to examine the relationship between acceptance of nociceptive stress at peripheral tissue and response against the stress at the central nervous system. We obtained significant results as follow. (1) Formalin test which was acute nociceptive stress model induced rapid neuroendocrine response in the hypothalamus. (2) Immediate early gene expression which was widely used for indication of activated of neurons was observed in the dorsal horn of the spinal cord and the hypothalamic paraventricular nucleus after nociceptive stress. (3) Receptor-activated Ca2+-channels such as transient receptor potential involved in processing nociceptive stress in the peripheral tissue.
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[Journal Article] Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptorβ
Author(s)
Gabbi C, Kong X, Suzuki H, Kim HJ, Gao M, Jia X, Ohnishi H, Ueta Y, Warner M, Guan Y, Gustafsson JÅ
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DOI
Peer Reviewed
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[Journal Article] Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats
Author(s)
Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y
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DOI
Peer Reviewed
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[Journal Article] Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat
Author(s)
Suzuki H, Kawasaki M, Ohnishi H, Otsubo H, Ohbuchi T, Katoh A, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y
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DOI
Peer Reviewed
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[Journal Article] Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats
Author(s)
Suzuki H, Onaka T, Kasai M, Kawasaki M, Ohnishi H, Otsubo H, Saito T, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y
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DOI
Peer Reviewed
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[Presentation] Expression of the hypothalamic feeding-regulating peptides is independent of serum calcium level in cachectic syndromes.2009
Author(s)
Suzuki, H. Hashimoto, H. Kawasaki, M. Azuma, Y. Otsubo, H. Fujihara, H. Ohnishi, H. Onuma, E. Yamada-Okabe, H. Takuwa, Y. Ogata, E. Nakamura, T. & Ueta, Y.
Organizer
36th International Congress Of Physiological Sciences
Place of Presentation
Kyoto, Japan
Year and Date
20090727-0801
