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2011 Fiscal Year Final Research Report

The roles of sex hormone and gender difference for spinal cord protection in spinal cord ischemia

Research Project

  • PDF
Project/Area Number 21591970
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGifu University

Principal Investigator

IIDA Hiroki  岐阜大学, 医学系研究科, 教授 (30159561)

Co-Investigator(Kenkyū-buntansha) IIDA Mami  岐阜大学, 医学系研究科, 非常勤講師 (80350859)
Project Period (FY) 2009 – 2011
Keywords性ホルモン / エストロジェン / リモートプレコンディショニング
Research Abstract

We evaluated the tissue oxygen partial pressure of spinal cord(PsptO2) following aortic cross-clamping and-unclamping, and then clarified the mechanism of improvement in the PsptO2 following spinal ischemia observed with remote ischemic preconditioning(RIPC) or intravenous estrogen in rabbits. In isoflurane anesthetized rabbits(n=36), we prepared for measurement of PsptO2 following aortic cross-clamping using tissue PO2 monitoring. In the first set of experiment, we allocated 18 animals into 3 groups,(a) control group ; n=6,(b) RIPC group ; n=6,(c) glibenclamide pretreatment(0. 3mg/kg) group ; n=6. In the second set of experiment, we also allocated 18 animals into 3 groups,(d) control group ; n=6,(e) estrogen(17ss estradiol : 20μg) group ; n=6,(f) fulvestrant pretreatment(1mg/kg) group ; n=6. RIPC improved deterioration of the values in PsptO2 at 20 min after aortic cross-clamping and 0, 2, 5 min after aortic unclamp. The improvement was diminished by pretreatment of glibenclamide. Administration of 17s estradiol improved deterioration of the values in PsptO2 at 20 min after aortic cross-clamping and 0, 2, 5 min after aortic unclamp. The improvement was diminished by pretreatment of fulvestrant.
In conclusion, after aortic cross-clamping, the RIPC performed improves the deterioration in PsptO2 through the KATP channel activation and 17ss estradiol improves the deterioration in PsptO2 through the estrogen receptor activation.

  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (10 results) Book (4 results)

  • [Journal Article] Case report : central venous catheterization via internal jugular vein with associated formation of perioperative venous thrombosis during surgery in the prone position2012

    • Author(s)
      Minami K, Iida M, Iida H.
    • Journal Title

      J Anesth.[ Epub ahead of print]

    • Peer Reviewed
  • [Journal Article] うつ病患者に対する修正型電気摩擦療法による脳血流の変化2012

    • Author(s)
      上松友季, 中村好美, 天野雄平, 田辺久美子, 飯田宏樹
    • Journal Title

      麻酔

      Volume: 61 Pages: 126-129

    • Peer Reviewed
  • [Journal Article] プロタミン投与後にアナフィラキシー様ショックを起こした症例2012

    • Author(s)
      山田忠則, 鬼頭和裕, 太田宗一郎, 大畠博人, 飯田宏樹
    • Journal Title

      臨床麻酔

      Volume: 36 Pages: 537-538

    • Peer Reviewed
  • [Journal Article] 術中に用いるオピオイドの種類によるベクロニウム使用料の比較2012

    • Author(s)
      長瀬清, 飯田宏樹
    • Journal Title

      麻酔

      Volume: 61 Pages: 291-298

    • Peer Reviewed
  • [Journal Article] Anesthesia and cerebrospinal microcirculation : assessment using cranial-and spinal-window techniques2012

    • Author(s)
      Iida H, Iida M, Takenaka M.
    • Journal Title

      J Anesth

      Volume: 26 Pages: 143-146

    • Peer Reviewed
  • [Journal Article] 慢性痛に対するオピオイドオピオイド治療の適応と患者選択2012

    • Author(s)
      松本茂美, 飯田宏樹
    • Journal Title

      Anet

      Volume: 16(1) Pages: 3-6

    • Peer Reviewed
  • [Journal Article] 全身麻酔下での人工膝関節置換術-フェンタニル持続静注を選択呼吸抑制にも注意2011

    • Author(s)
      飯田美紀, 飯田宏樹
    • Journal Title

      LiSA

      Volume: 18 Pages: 258-261

    • Peer Reviewed
  • [Journal Article] 周術期禁煙2011

    • Author(s)
      飯田宏樹, 加藤真有美
    • Journal Title

      臨床麻酔

      Volume: 35 Pages: 1095-1103

    • Peer Reviewed
  • [Journal Article] Midazolam suppresses interleukin1 ss-induced interleukin-6 release from rat glial cells2011

    • Author(s)
      Tanabe K, Kozawa O, Iida H.
    • Journal Title

      J Neuroinflammation

      Volume: 8 Pages: 68

    • Peer Reviewed
  • [Journal Article] 脊髄保護のための麻酔法2011

    • Author(s)
      飯田宏樹
    • Journal Title

      Anet

      Volume: 15 Pages: 22-26

    • Peer Reviewed
  • [Journal Article] ハンチントン舞踊病患者に対するスガマデクスの使用経験2011

    • Author(s)
      加藤真有美, 山田裕子, 熊澤昌彦, 竹中元康, 飯田宏樹
    • Journal Title

      臨床麻酔

      Volume: 35 Pages: 857-859

    • Peer Reviewed
  • [Journal Article] 慢性疼痛に対する新しい薬物-新しい薬物を含む治療法選択の考え方-2011

    • Author(s)
      飯田宏樹, 山口忍
    • Journal Title

      臨床整形外科

      Volume: 46 Pages: 31-316

    • Peer Reviewed
  • [Journal Article] 脳脊髄循環からみた脊椎外科・大血管外科における脊髄保護2011

    • Author(s)
      飯田宏樹
    • Journal Title

      日臨麻会誌

      Volume: 31 Pages: 193-201

    • Peer Reviewed
  • [Journal Article] 安全面と効率面からみた難治性疼痛治療2011

    • Author(s)
      飯田宏樹
    • Journal Title

      ペインクリニック

      Volume: 32 Pages: 317-318

    • Peer Reviewed
  • [Journal Article] Preliminary study of the efficacy of radiofrequency lesions of stellate ganglion in chronic pain patients2010

    • Author(s)
      Yamaguchi S, Iida H, Sumi K, Takenaka M, Yoshimura N, Dohi S.
    • Journal Title

      Pain Med

      Volume: 11 Pages: 142-144

    • Peer Reviewed
  • [Journal Article] 喫煙2010

    • Author(s)
      飯田宏樹
    • Journal Title

      麻酔

      Volume: 59 Pages: 838-843

    • Peer Reviewed
  • [Journal Article] 拘束性肺疾患2010

    • Author(s)
      福岡尚和, 飯田宏樹
    • Journal Title

      麻酔

      Volume: 59 Pages: 833-837

    • Peer Reviewed
  • [Journal Article] Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats2010

    • Author(s)
      Iida H, Iida M, Takenaka M, Fukuoka N, Dohi S.
    • Journal Title

      J Thromb Thrombolys

      Volume: 29 Pages: 483-488

    • Peer Reviewed
  • [Journal Article] Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells2010

    • Author(s)
      Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O.
    • Journal Title

      J Neuroinflamm

      Volume: 7 Pages: 16

    • Peer Reviewed
  • [Journal Article] 交感神経ブロックおよびナトリウムチャネル遮断薬が著効し、長期経過で運動障害・骨脱灰が回復したCRPSの1症例2010

    • Author(s)
      早川洋子, 飯田宏樹, 鷲見和行, 田口佳広, 山口忍, 吉村文貴, 竹中元康, 土肥修司
    • Journal Title

      ペインクリニック

      Volume: 31 Pages: 509-511

    • Peer Reviewed
  • [Journal Article] The association between the initial end-tidal carbon dioxide difference and the lowest arterial oxygen tension value obtained during one-lung anesthesia with propofol or sevoflurane2009

    • Author(s)
      Fukuoka N, Iida H, Akamatsu S, Nagase K, Iwata H, Dohi S
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: 23 Pages: 775-779

    • Peer Reviewed
  • [Journal Article] A case of cervicogenic ipsilateral shoulder pain after thoracic surgery2009

    • Author(s)
      Iida H, Sumi K, Yamaguchi S, Takenaka M, Dohi S
    • Journal Title

      J Cardiothorac Vasc Aneth

      Volume: 23 Pages: 853-854

    • Peer Reviewed
  • [Journal Article] A Case of Cesarean Section with a Preoperatively Undiagnosed Placenta Percreta2009

    • Author(s)
      Minami K, Iida H, Sakakibara I, Dohi S
    • Journal Title

      Anesthesia and Resuscitation

      Volume: 45 Pages: 69-70

    • Peer Reviewed
  • [Journal Article] Involvement of Rho-kinase in tumor necrosis factor-α-induced interleukin-6 release from C6 glioma cells2009

    • Author(s)
      Yamaguchi S, Tanabe K, Takai S, Matsushima-Nishiwaki R, Adachi S, Iida H, Kozawa O, Dohi s
    • Journal Title

      Neurochemistry International

      Volume: 55 Pages: 438-445

    • Peer Reviewed
  • [Journal Article] Comparative effects of ultra-short-acting ss 1-blockers on voltage-gated tetrodotoxin-resistant Na+channels in rat sensory neurons2009

    • Author(s)
      Tanahashi S, Iida H, Dohi S, Oda A, Osawa Y, Yamaguchi S
    • Journal Title

      Eur J Anaesthesiol

      Volume: 26 Pages: 196-200

    • Peer Reviewed
  • [Presentation] Mechanisms underlying endothelial dysfunction by acute cigarette smoking in rat2011

    • Author(s)
      Iida M, Iida H, Takenaka M.
    • Organizer
      26^<th> International Symposium on Cerebral Blood Flow Metabolism and Function
    • Place of Presentation
      Barcelona
    • Year and Date
      20110525-28
  • [Presentation] Nicorandil prevents the pial arteriolar endothelium from oxidative stress induced by smoking in rats2011

    • Author(s)
      Iwata K, Iida M, Fukuoka N, Tanabe K, Takenaka M, Iida H.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-19
  • [Presentation] Efficiency of facet rhizotomy for patients with recurrent lumbar pain after a spinal fusion2011

    • Author(s)
      Yoshimura N, Takenaka M, Yamaguchi S, Miyamoto M, Matsumoto S, Iida H.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
  • [Presentation] Effects of intravenous anesthetics and sedatives on mucin production in cultured human airway epithelial cells2011

    • Author(s)
      SugiyamaY, Tanabe K, Iida H.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
  • [Presentation] Intravenous Flurbiprofen Prevents Mesenteric Traction Syndrome-Evaluation with FloTrac^<(R)> Sensor2010

    • Author(s)
      Minami K, Takada M, Murata T, Inoue C, Sudani T, Iida H.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      San Diego
    • Year and Date
      20101016-20
  • [Presentation] Preconditioning with estrogen lmproves the deterioration of the tissue oxygen partial pressure of spinal cord after Aortic Cross-Clamping2010

    • Author(s)
      Takenaka M, Iida M, Iida H.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      San Diego
    • Year and Date
      20101016-20
  • [Presentation] The effects of varenicline associated with acute smoking on the endothelial function in cerebral vessels in rats2010

    • Author(s)
      Iida M, Iida H, Takenaka M, Tanabe K.
    • Organizer
      American Soceity of Anesthesiologists
    • Place of Presentation
      San Diego
    • Year and Date
      20101016-20
  • [Presentation] RIPC Improves the Deterioration of PsptO_2 after Aortic Cross-Clamp through K-_<ATP> Channel Activation2009

    • Author(s)
      Takenaka M, Iida H, Iida M, Dohi S
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-10-18
  • [Presentation] Diabetes-Incuced Tactile Allodynia Involves Activation of Adenylyl Cyclase in Rat Sensory Neurons2009

    • Author(s)
      Sugiyama Y, Iida H, Dohi S
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-10-17
  • [Presentation] Effects of Cilostazol and Aspirin on the Cerebral Endothelial Dysfunction Caused by Smoking in Rats2009

    • Author(s)
      Iida M, Iida H, Tanenaka M, Fukuoka N, Dohi S
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-10-17
  • [Book] よくわかる神経ブロック法2011

    • Author(s)
      飯田宏樹,福井弥己郎,伊達久,安部洋一郎
    • Publisher
      中外医学社
  • [Book] いきなり名医!見わけが肝心、不定愁訴-訴えの見極め方と治療の極意-2010

    • Author(s)
      飯田宏樹,森田浩之
    • Publisher
      日本医事新報社
  • [Book] 麻酔科トラブルシューティング2010

    • Author(s)
      飯田宏樹:高崎眞弓,河本昌志,川真田樹人,岡本博嗣
    • Publisher
      (株)文光堂
  • [Book] 痛みの評価.麻酔科研修ノート2010

    • Author(s)
      山口忍,飯田宏樹,稲田英一
    • Publisher
      (株)診断と治療社

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Published: 2013-07-31  

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