2011 Fiscal Year Final Research Report
Clarify the role of mu receptor endocytosis in spinal analgesia and opioid tolerance
| Project/Area Number |
21591972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shimane University |
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Principal Investigator |
SAITO Yoji 島根大学, 医学部, 教授 (50162243)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Tatsuya 島根大学, 医学部, 講師 (00372681)
NIKAI Tetsuro 島根大学, 医学部, 講師 (20314643)
IMAMACHI Noritaka 島根大学, 医学部, 講師 (40325048)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オピオイド作動薬 / μオピオイド受容体細胞内動態 / 耐性 / 脊髄鎮痛 |
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| Research Abstract |
Oxycodone induced mu opioid receptor endocytosis in different manner, such as DAMGO or morphine. It was thought that this result could clarify the role of mu opioid receptor endocytosis in spinal analgesia and opioid tolerance.
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