Spinal cord protection by the activation of Akt(protein kinase B)

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUMOTO Mishiya 山口大学, 大学院・医学系研究科, 教授 (60243664)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Atsuo 山口大学, 医学部附属病院, 助教 (50379971) ; WAKAMATSU Hiroya 山口大学, 医学部附属病院, 講師 (80379966) ; FUKUDA Shiro 山口大学, 大学院・医学系研究科, 講師 (70322245)
• Project Period (FY): 2009 – 2011
• Keywords: 脊髄虚血 / インスリン様成長因子1 / エリスロポエチン

Research Abstract

One of the devastating complications after thoracoabdominal aortic surgery is paraplegia. Paraplegia is thought to be a result of spinal cord ischemia during aortic occlusion. To protect against ischemic spinal cord injury, many drugs have been tested in animal experiments. However, no drugs have been established as being protective in the clinical setting. In this study, we found that the combination of erythropoietin and insulin-like growth factor 1 given just after reperfusion protects against ischemic spinal cord injury in a transient spinal cord ischemia model in rabbits.

Research Products

• [Journal Article] 麻薬は虚血性脊髄障害を増悪させない (2012)
  • Author(s): 松本美志也、白澤由美子、石田和慶、福田志朗、山下敦生
  • Journal Title: 日本臨床麻酔学会誌 Volume: 32巻 Pages: 359-365
  • Peer Reviewed
• [Journal Article] 神経麻酔を考える-基礎から臨床へ- (2010)
  • Author(s): 松本美志也
  • Journal Title: 麻酔 Volume: 59巻 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits? (2009)
  • Author(s): Yumiko Shirasawa, Mishiya Matsumoto, Manabu Yoshimura, Atsuo Yamashita, Shiro Fukuda, Kazuyoshi Ishida, Takefumi Sakabe
  • Journal Title: J Anesth Volume: vol23 Pages: 242-248
  • Peer Reviewed
• [Presentation] 脊髄虚血 (2011)
  • Author(s): 松本美志也
  • Organizer: 第81回獣医麻酔外科学会招待講演
  • Place of Presentation: 福岡国際会議場福岡
  • Year and Date: 2011-01-29
• [Presentation] 中枢神経系における一酸化窒素の役割 (2010)
  • Author(s): 松本美志也
  • Organizer: 第14回日本医療ガス学会学術集会
  • Place of Presentation: 金沢アートホール金沢
  • Year and Date: 2010-11-20
• [Presentation] オピオイドは虚血性脊髄障害を増悪しない (2010)
  • Author(s): 松本美志也
  • Organizer: 日本臨床麻酔学会第30回大会
  • Place of Presentation: 徳島グランヴィリオホテル徳島
  • Year and Date: 2010-11-04
• [Presentation] Kazuyoshi Ishida Neuroprotective synergy of erythropoietin and insulin-like growth factor 1 in spinal cord ischemia (2010)
  • Author(s): Mishiya Matsumoto, Manabu Yoshimura, Atsuo Yamashita, Shiro Fukuda
  • Organizer: American Society of Anesthesiologists Annual Meeting 2010
  • Place of Presentation: 米国San Diego
  • Year and Date: 2010-10-18
• [Presentation] エリスポエチンの脳・脊髄保護効果 (2010)
  • Author(s): 松本美志也、吉村学、山下敦生、福田志朗、石田和慶
  • Organizer: 日本心臓血管麻酔学会第15回学術大会
  • Place of Presentation: ザ・プリンスパークタワー東京東京
  • Year and Date: 2010-10-10
• [Presentation] 胸腹部大動脈瘤手術時の脊髄保護 (2010)
  • Author(s): 松本美志也
  • Organizer: 日本麻酔科学会中国・四国支部第47回学術集会
  • Place of Presentation: 米子コンベンションセンタービッグシップ米子
  • Year and Date: 2010-10-10
• [Presentation] 神経麻酔を考える:基礎から臨床へ (2010)
  • Author(s): 松本美志也
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡国際会議場福岡
  • Year and Date: 2010-06-05
• [Presentation] 一過性脊髄虚血後の神経障害に対するerythropoietinとinsulin-like growth factor 1の保護効果 (2009)
  • Author(s): 吉村学、松本美志也、山下敦生、若松弘也、福田志朗、石田和慶、坂部武史
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸ポートピアホテル神戸
  • Year and Date: 2009-08-18