2011 Fiscal Year Final Research Report

Protective potentials of erythropoietin against neurotoxicity of general anesthetics on immature brain.

Research Project

Project/Area Number	21591980
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Yokohama City University
Principal Investigator	ECHIGO Noriyuki 横浜市立大学, 医学研究科, 客員准教授 (00363797)
Co-Investigator(Kenkyū-buntansha)	ANDOH Tomio 横浜市立大学, 医学研究科, 客員教授 (00193110) KAMIYA Yoshinori 横浜市立大学, 医学部, 助教 (90381491)
Project Period (FY)	2009 – 2011
Keywords	エリスロポエチン / 新生児 / 神経保護 / 神経細胞死 / 麻酔薬
Research Abstract	General anesthetics are shown to induce wide spread apoptosis in the developing brain. We studied if erythropoietin (Epo) affords protection against anesthetic-induced neurotoxicity in neonatal rats. We found that neuroapoptosis was induced in the cerebral cortex and hypocampus after 6 hour exposure to general anesthetics. Intranasal and intraperitoneal administration of Epo failed to inhibit apoptosis. The results suggest that Epo is not effective in inhibiting anesthetic-induced neurotoxicity in immature brain.

(2 results)