2012 Fiscal Year Final Research Report
Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats
| Project/Area Number |
21591984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Satoki 奈良県立医科大学, 医学部, 助教 (50295789)
KAWAGUCHI Masahiko 奈良県立医科大学, 医学部, 教授 (60275328)
SASAOKA Noriyuki 奈良県立医科大学, 医学部, 助教 (70364073)
FURUYA Hitosi 奈良県立医科大学, 医学部, 教授 (70183598)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROTA Kiichi 京都大学, 医学(系)研究科(研究院), 講師 (00283606)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 蘇生学 / 脳虚血 |
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| Research Abstract |
Recent evidence indicated that n-propyl gallate (PG), a synthetic antioxidant, activates hypoxia-inducible factor 1 (HIF-1) under normoxic conditions in cultured cells. The present study was conducted to test the hypothesis that the administration of PG may attenuate neuronal injury in a rat model of forebrain ischemia. The results indicated that intraperitoneal administration of n-propyl galate may have neuroprotective effects in a model of moderate(8min), but not severe(10min), forebrain ischemia in rats.
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