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2012 Fiscal Year Final Research Report

Analysis of volatile anestheics: involvement of intracellular signaling and neural transmission

Research Project

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Project/Area Number 21591988
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJuntendo University

Principal Investigator

NISHIMURA Kinya  順天堂大学, 医学部, 教授 (80164581)

Project Period (FY) 2009 – 2012
Keywords吸入麻酔薬 / 麻酔興奮期 / tonicGABA電流
Research Abstract

Suppression of movement during induction of anesthesia is mediated through subcortical structures. We studied the effects of a brief 5-min application of a clinically relevant concentration of sevoflurane on the electrophysiological activities of the medium spiny neurons of the stratum in brain slice preparations, using a whole-cell patch-clamp technique. We found that sevoflurane depressed the peak, as well as the net, charge transfer of intrastriatally evoked inhibitory postsynaptic currents much more strongly than those of excitatory postsynaptic currents. And this inhibition was accompanied by an elevated paired-pulse ratio. The strong suppression of eIPSCs paralleled a significant suppression of the spontaneous EPSCs. These results suggest that, in contrast to its effects on other brain structures, sevoflurane shifts the balance between synaptic excitation and inhibition in the direction of excitation in the stratum, thereby causing involuntary movements during induction of anesthesia by sevoflurane.And, Sevoflurane has been shown to enhance two types of GABAergic inhibition: a synaptic form (phasic inhibition) regulating neural excitability via the activation of postsynaptic GABAA receptors by intermittent GABA release from presynaptic terminals;and a persistent tonic form (tonic inhibition) generated by continuous activation of extrasynaptic GABAA receptors by low concentrations of ambient GABA.

  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (9 results)

  • [Journal Article] Imbalanced suppression of excitatoryand inhibitory synaptic transmission ontomouse striatal projection neurons duringinduction of anesthesia with sevofluranein vitro2012

    • Author(s)
      Oose Y,Miura M,, Inoue R, Andou,N,Aosaki T, Nishimura K.
    • Journal Title

      Eur J Neurosci

      Volume: 35(9) Pages: 1396-405

  • [Journal Article] Thoracoscopic Plication forDiaphragmatic Eventration in a Neonate2012

    • Author(s)
      Takahashi T ,Nishimura K, et al
    • Journal Title

      AnnThorac Cardiovasc Surg

  • [Journal Article] Pulmonary artery size as an indicationfor thoracoscopic repair of congenitaldiaphragmatic hernia in neonates2012

    • Author(s)
      Okazaki T,Nishimura K,,et al
    • Journal Title

      PediatrSurg Int

      Volume: 28 Pages: 883-6

  • [Journal Article] 脳内神経ネットワークからみた吸入麻酔薬の作用機序の解析2012

    • Author(s)
      工藤 治,西村欣也,稲田英一
    • Journal Title

      臨床麻酔

  • [Journal Article] Indications for thoracoscopic repair ofcongenital diaphragmatic hernia inneonates2011

    • Author(s)
      Okazaki T . Nishimura K,. et al
    • Journal Title

      Pediatr Surg Int

      Volume: 27 Pages: 35-8

  • [Journal Article] 新生児, 乳児の肥厚性幽門狭窄症の麻酔管理におけるレミフェンタニル併用時の麻酔薬投与量, 抜管時間の検討2011

    • Author(s)
      渡辺朝香,工藤 治,西村欣也,他
    • Journal Title

      日本臨床麻酔学会誌

      Volume: Vol,31 Pages: 5411-5412

  • [Journal Article] MEPモニタリングと側彎症に対する周術期管理2011

    • Author(s)
      西村欣也,工藤 治,渡辺浅香,他
    • Journal Title

      臨床麻酔

      Volume: 35 Pages: 81-87

  • [Journal Article] Acetylcholine-dopamine balancehypothesis in the striatum: anupdate2010

    • Author(s)
      Aosaki T, Nishimura K, .et al
    • Journal Title

      Geriatr Gerontol Int

      Pages: S148-57

  • [Journal Article] The benefit of stay sutures duringthoracoscopic esophagoesophagostomy inpatients with esophageal atresia: atechnical report2010

    • Author(s)
      Shimotakahara A, Nishimura K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 26 Pages: 443-6

URL: 

Published: 2014-08-29  

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