2011 Fiscal Year Final Research Report
Protective effect on cardiac mitochondria in anesthetic postconditioning
| Project/Area Number |
21591989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MIO Yasushi 東京慈恵会医科大学, 医学部, 准教授 (00266686)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ミトコンドリア / 心筋 / 臓器保護 |
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| Research Abstract |
Volatile anesthetic directly protects mitochondrial function independently from cytosolic signaling pathways in anesthetic postconditioning. Nicorandil, coronary vasodilatation agent used in the management of angina during perioperative period, also directly protects isolated mitochondrial bioenergetics through nitric oxide, independent of its effects on the cytosolic signal transduction cascade. These results indicate that immediate protective benefits on mitochondrial function independently from the cytosolic environment may contribute to the cardioprotective effects provided by pharmacological postconditioning.
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