2011 Fiscal Year Final Research Report

Protective effect on cardiac mitochondria in anesthetic postconditioning

Research Project

Project/Area Number	21591989
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Jikei University School of Medicine
Principal Investigator	MIO Yasushi 東京慈恵会医科大学, 医学部, 准教授 (00266686)
Project Period (FY)	2009 – 2011
Keywords	ミトコンドリア / 心筋 / 臓器保護
Research Abstract	Volatile anesthetic directly protects mitochondrial function independently from cytosolic signaling pathways in anesthetic postconditioning. Nicorandil, coronary vasodilatation agent used in the management of angina during perioperative period, also directly protects isolated mitochondrial bioenergetics through nitric oxide, independent of its effects on the cytosolic signal transduction cascade. These results indicate that immediate protective benefits on mitochondrial function independently from the cytosolic environment may contribute to the cardioprotective effects provided by pharmacological postconditioning.

(6 results)