2011 Fiscal Year Final Research Report
Characterizing pharmacodynamic interactions of anesthetics on parallel/serial neural circuit model
| Project/Area Number |
21591991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬物相互作用 / 麻酔作用機序 / 神経ネットワーク / 相乗効果並列回路 / 薬力学 / 薬物動態 |
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| Research Abstract |
Producing the anesthetic state is at least a two drug process typically consisting of a hypnotic and an opioid. Models that adequately characterize pharmacodynamic drug interactions are important to understanding anesthetic behavior. We proposed the parallel/serial neural circuit model and characterized its mathematical behavior. The model predicted that the additive interaction occurred only when the mechanism of anesthetics were identical. Some combination of anesthetics showed additive, even though their potencies on molecular level were different. We showed the condition required for the clinically additive interaction using the parallel/serial circuit model.
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