2011 Fiscal Year Final Research Report
Role of endogenous prostanoids in vascular remodeling
| Project/Area Number |
21591993
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Keywords | 内因性プロスタノイド / 血管リモデリング |
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| Research Abstract |
The intimal areas and medial areas two weeks after ligation of left common carotid arteries increased in both wild-type (WT) and EP4 receptor knockout (EP4^<-/->) mice. The intimal area four weeks after ligation was significantly increased in the ligated WT arteries compared with EP4^<-/-> arteries. I/M ratio and stenotic ration four weeks after blood flow cessation were also significantly increased in the ligated WT arteries compared with EP4^<-/->arteries. These results indicate that endogenous PGE2 plays an important role in intimal hyperplasia caused by blood-flow cessation via EP4 receptor.
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Research Products
(47 results)
