2011 Fiscal Year Final Research Report
Neurotoxicity induced by opiates after spinal cord contusion injury
| Project/Area Number |
21592002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523)
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
TANAKA Satoshi 信州大学, 医学部附属病院, 講師 (60293510)
KITO Takeshi 信州大学, 医学部, 非常勤講師 (90195313)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脊髄損傷 / オピオイド / 神経毒性 |
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| Research Abstract |
A single dose of intrathecal(IT) morphine for the acute phase of mild thoracic spinal cord injury(SCI) increased muscle tone of the hindlimbs and aggravated residual locomotor function predominantly viaμ-opioid receptor activation in the spinal cord. In contrast, continuous infusion of IT morphine not only aggravates locomotor function but also attenuates functional recovery without involving activation of the opioid receptor. These results indicate that the mechanisms of the aggravation of locomotor dysfunction by continuous infusion of IT morphine may be different from that of a single dose of IT morphine. Caution is warranted when morphine are continuously administered for alleviating the pain in the acute phase of SCI.
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