Bran-New Indicator of the Management for Living Donor Liver Transplantation : Exhaled Carbon Monoxide

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Okayama University
• Principal Investigator: MATSUMI Masaki 岡山大学, 医学部, 客員研究員 (70219476)
• Co-Investigator(Kenkyū-buntansha): MORITA Kiyoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40108171) ; MORIMATSU Hiroshi 岡山大学, 岡山大学病院, 講師 (30379797) ; TAKAHASHI Toru 岡山大学, 岡山大学病院, 助教 (40252952)
• Project Period (FY): 2009 – 2011
• Keywords: 周術期管理 / 肝臓移植 / 虚血再潅流障害 / 一酸化炭素 / Heme oxygenase-1

Research Abstract

During living donor liver transplantation, several changes would be happen after ishcemia/reperfusion. Nowadyas, there is no definite indicator of these changes. Therefore, we examined whether exhaled carbon monoxide(CO) concentration would be the indicator of these changes during liver transplantation. As the results, we found that exhaled CO concentration had a correlation with intra-hepatic heme oxygenase-1 gene expression and protein expression as well. This result indicated that exhaled CO concentration would be a novel therapeutic marker of ishcemia/reperfusion injury.

Research Products

• [Journal Article] Heme breakdown and ischemia/reperfusion injury in grafted liver during living donor liver transplantation. (2012)
  • Author(s): Matsumi, J., Morimatsu, H., Matsusaki, T., Kaku, R., Shimizu, H., Takahashi, T., Yagi, T., Matsumi, M. and Morita, K
  • Journal Title: Int J Mol Med Volume: 29 Pages: 135-40
  • Peer Reviewed
• [Journal Article] Heme Proteins, Heme Oxygenase-1 and Oxidative Stress. (2012)
  • Author(s): Morimatsu, H., Takahashi, T., Shimizu, H., Matsumi, J., Kosaka, J., and Morita, K.
  • Journal Title: InTech Pages: 109-124
  • Peer Reviewed
• [Journal Article] An increase in exhaled CO concentration in systemic inflammation/sepsis. (2010)
  • Author(s): Morimatsu, H., Takahashi, T., Matsusaki, T., Hayashi, M., Matsumi, J., Shimizu, H., Matsumi, M. and Morita, K.
  • Journal Title: J Breath Res Volume: 4 Pages: 047103
  • Peer Reviewed
• [Presentation] 生体肝移植における肝Heme Oxygenase-1 mRNAと呼気一酸化炭素濃度の関係 (2010)
  • Author(s): 松三絢弥、清水裕子、森松博史、高橋徹、森田潔
  • Organizer: 日本麻酔学会年次総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] Relationship between exhaled carbon monoxide and oxidative stress in ischemic-reperfusion injury during living donor liver transplantation (2009)
  • Author(s): Matsumi J, Moritasu H, Shimizu H, Takahashi T, Morita K.
  • Organizer: Annual meeting of the European Society of Anesthesiologists
  • Place of Presentation: ミラノ
  • Year and Date: 2009-06-06