Evaluation of the anti-tumor effect of microRNA on cancer metastasis under the general anesthesia

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyushu University
• Principal Investigator: SHINICHIRO Yoshitake 九州大学, 大学病院, 講師 (80315142)
• Co-Investigator(Kenkyū-buntansha): ISHII Hideshi 大阪大学, 医学系研究科, 寄付講座教授 (10280736)
• Project Period (FY): 2009 – 2011
• Keywords: microRNA / 骨髄 / 転移 / 再発 / ヒストンファミリー

Research Abstract

Under the general anesthesia, host cells in bone marrow(BM) might play a consecutive role in recurrence or metastasis in gastric cancer(GC) cases. We have focused on gene/miR axis in host cells and compared the gene/miR axis in BM between from stage IV and stage I GC cases. Then, we identified significant 106 gene/miR axis and found that HIST family/miR760 axis was the most clinical significant one in GC cases among them. Therefore, we will evaluate the magnitude of the level of miR/gene axis on the cancer metastasis affected by general anesthesia.

Research Products

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• [Journal Article] Cancer stem cell (2011)
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• [Journal Article] Molecular biology of colon cancer (2011)
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• [Journal Article] Expression of CLDN1 in colorectal cancer (2011)
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• [Journal Article] Reprogramming of mouse and human cells to pluripotency using mature microRNAs (2011)
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• [Journal Article] The significance of PITX2 overexpression in human colorectal cancer (2011)
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• [Journal Article] MicroRNA miR-125b is a prognostic marker in human colorectal cancer (2011)
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• [Journal Article] The future prospects and subject of the liver cancer stem cells study for the clinical application (2011)
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• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients (2011)
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• [Journal Article] Utility of myocardial fractional flow reserve for prediction of restenosis following sirolimus-eluting stent implantation (2011)
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• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
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• [Journal Article] Significance of Lgr5(+ ve) cancer stem cells in the colon and rectum (2011)
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• [Journal Article] Significance of Lgr5(+ ve) cancer stem (2011)
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• [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma (2011)
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• [Journal Article] STC2 : a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma (2011)
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• [Journal Article] A case of lateral lymph node metastasis of submucosal rectal cancer (2010)
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• [Journal Article] A long-term survival case of rectal cancer with Virchow' s lymph node metastasis by multimodality therapy (2010)
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  • Journal Title: Gan To Kagaku Ryoho Volume: 37(12) Pages: 2545-7
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• [Journal Article] Clinical significance of ASB9 in human colorectal cancer (2010)
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• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles (2010)
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  • Journal Title: Gut Volume: 59(11) Pages: 1457-64
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• [Journal Article] Development of cancer stem cell research in gastrointestinal tumors (2010)
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  • Journal Title: Rinsho Ketsueki Volume: 51(8) Pages: 672-8
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• [Journal Article] Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients (2010)
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  • Journal Title: Clin Cancer Res Volume: 16(18) Pages: 4625-35
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• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells (2010)
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• [Journal Article] Perspective beyond cancer genomics (2010)
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• [Journal Article] Serum matrix-metalloproteinase-1 is a bona fide prognostic marker for colorectal cancer (2010)
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• [Journal Article] Properties and identification of cancer stem cells : a changing insight into intractable cancer (2010)
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• [Journal Article] Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer (2010)
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• [Journal Article] The clinical significance of vimentin-expressing gastric cancer cells in bone marrow (2010)
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• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer (2010)
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• [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer (2010)
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  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 大腸癌におけるEMTを制御し造腫瘍能と他文化能を有する遺伝子の臨床的意義と機能解析 (2009)
  • Author(s): 三森功士、横堀武彦、岩槻政晃、石丸神矢、秋吉清百合、永原誠、石井秀始、森正樹
  • Organizer: 第18回日本がん転移学会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-23