2011 Fiscal Year Final Research Report
A role of glycine transporter on spinal dorsal horn neuron through the pain sensation produced by neuropathic pain model
| Project/Area Number |
21592015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kansai University of Health Sciences (2010-2011)
Niigata University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATSUKA TERUMASA 関西医療大学, 保健医療学部, 教授 (30380752)
KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛管理学 |
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| Research Abstract |
We investigated the effect of glycine transporter in spinal dorsal horn neuron, but we could not find that effect. Therefore, we have demonstrated that d-serine in spinal dorsal horn neuron has two distinct actions, one is an excitatory action mediated by NMDA receptor, the other is an inhibitory action mediated by glycine receptor. Interestingly, the excitatory action by d-serine after peripheral nerve injury was more sensitive than physiological condition, whereas its inhibitory action after peripheral nerve injury was less than naive one.
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