2011 Fiscal Year Final Research Report
Vascular reactivity during anesthesia and shock in human arteries in vitro
| Project/Area Number |
21592018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 周術期管理学 |
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| Research Abstract |
We tested the effects of human peptides during anesthesia and shock on human vascular smooth muscle and vital reactions. A novel a novel isoindolin-1-one derivate, JM1232(-), directly dilated human gastroepiploic arteries in vitro in clinical doses and this drug suppressed the heart rate and blood pressure of rat dose-dependent manner. In addition, as to the relationship between blood sugar and insulin susceptibility during anesthesia, we measured a biomarker for blood sugar control, 1. 5AG, in patients with general anesthesia.
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[Journal Article] 麻酔とオレキシン(誌上抄読会)2011
Author(s)
白阪哲朗, 小田麻由, 日高康太郎, 須江宣俊, 石山健次郎, 太田尾剛, 矢野武志, 新福玄二, 柏田政利, 森信一郎, 鬼塚信, 指宿昌一郎, 恒吉勇男
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Journal Title
臨床麻酔
Volume: 35
Pages: 845-851
Peer Reviewed
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