2011 Fiscal Year Final Research Report
Analgesic actions of nicotine for postoperative acute pain-Investigation by using in vivo patch-clamp recording.
| Project/Area Number |
21592022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka City University |
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Principal Investigator |
MORI Takashi 大阪市立大学, 大学院・医学研究科, 准教授 (00336786)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛管理学 |
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| Research Abstract |
We have arranged experimental facility for in vivo patch-clamp method to record stable synaptic responses in rat spinal dorsal horn neurons. Spinal surface perfusion of nicotine dose-dependently increased the frequency and amplitude of inhibitory post-synaptic currents in rat dorsal horn neurons of spinal cord suggesting one of the nicotine's analgesic mechanisms in the spinal cord. However, intravenous administration of nicotine had no obvious effects on IPSCs. Actions of nicotine on excitatory post-synaptic currents, action potentials, and responses in acute pain model are yet to be determined.
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