Study on neuropathic pain associated with pre-diabetes and obese

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nigata University of Phermacy and Applied Life Sciences (2011); Wakayama Medical University (2009-2010)
• Principal Investigator: MAEDA Takehiko 新潟薬科大学, 薬学部, 教授 (50271010)
• Co-Investigator(Kenkyū-buntansha): KISHIOKA Shiroh 和歌山県立医科大学, 医学部, 教授 (60137255) ; KIGUCHI Norikazu 和歌山県立医科大学, 医学部, 講師 (90433341) ; KOBAYASHI Yuka 和歌山県立医科大学, 医学部, 助教 (20511562)
• Project Period (FY): 2009 – 2011
• Keywords: 疼痛管理学 / 生活習慣病

Research Abstract

We established a model for pre-diabetes with neuropathic pain(PDN). The model showed peripheral neuropathy, characterized by allodynia and histopathology associated with chronic inflammation. The model is useful for development of therapeutic treatment for PDN.

Research Products

• [Journal Article] レプチンと神経障害性疼痛 (2010)
  • Author(s): 前田武彦
  • Journal Title: 医学のあゆみ Volume: 233(7) Pages: 565
• [Journal Article] Macrophage inflammatory protein-1 α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation (2010)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
  • Journal Title: Pain Volume: 149 Pages: 305-315
  • URL: http://dx.doi.org/10.1016/j.pain.2010.02.025
  • Peer Reviewed
• [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation (2009)
  • Author(s): Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 106 Pages: 13076-13081
  • DOI: doi:10.1073/pnas.0903524106
  • Peer Reviewed
• [Presentation] 緩和医療における臨床研究・基礎研究とは (2011)
  • Author(s): 前田武彦
  • Organizer: 第61回日本薬学会近畿支部総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-22
• [Presentation] レプチンの神経障害性疼痛における役割 (2010)
  • Author(s): 前田武彦、木口倫一、小林悠佳、岸岡史郎
  • Organizer: 第15回アディポサイエンス研究会シンポジウム
  • Place of Presentation: 吹田
  • Year and Date: 2010-08-25
• [Presentation] アディポカインは神経障害性疼痛の形成を調節する (2009)
  • Author(s): 前田武彦、岸岡史郎
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-19