2011 Fiscal Year Final Research Report
The effects of the gene expression of D-serine related enzymes on psychiatric symptom induced by ketamine
Project/Area Number |
21592026
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | Tokai University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
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Project Period (FY) |
2009 – 2011
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Keywords | ケタミン / 精神症状 / NMDA受容体 / Dセリン / 遺伝子発現 |
Research Abstract |
The levels of serine racemase mRNAs in forebrain areas significantly decreased after subchronic administration of ketamine. In contrast, subchronic ketamine administration produced a significant increase in the mRNA expression of D-amino acid oxidase in the midbrain. These findings suggest that there is a relationship be-tween the gene expression of the D-serine-related enzymes and the blockade of the NMDA receptors.
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