2011 Fiscal Year Final Research Report
Exploratory study of prognostic and therapeutic target moleculars in advanced prostate cancer
| Project/Area Number |
21592029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HABUCHI Tomonori 秋田大学, 大学院・医学系研究科, 教授 (00293861)
HORIKAWA Yohei 秋田大学, 医学部, 講師 (40361232)
NARITA Shintaro 秋田大学, 医学部, 講師 (40396552)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍学 |
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| Research Abstract |
Individual genetic variations may have a significant influence on the survival of metastatic prostate cancer (PCa) patients. We aimed to identify target genes and their variations involved in the survival of PCa patients using a single nucleotide polymorphism (SNP) panel. A total of 185 PCa patients with bone metastasis at initial diagnosis were analyzed. Each patient was genotyped using a Cancer SNP panel that contained 1421 SNPs in 408 cancer-related genes. SNPs associated with the survival were screened by log rank test. Fourteen SNPs in six genes, XRCC4, PMS1, GATA3, IL13, CASP8, and IGF1, were identified to have statistically significant association with the cancer-specific survival. The cancer-specific survivals of patients grouped according to the number of risk genotypes of 6 SNPs selected from the 14 SNPs differed significantly (0-1 vs 2-3 vs 4-6 risk genotypes, P = 7.20 × 10-8). The high-risk group was independently associated with the survival in a multivariate analysis that included conventional clinicopathological variables (P=1.8x10-7). We identified 14 SNPs in 6 cancer-related genes which were associated with poor survival in patients with metastatic PCa. A panel of SNPs may help predict the survival of those patients.
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