2011 Fiscal Year Final Research Report
Identification of androgen-response genes related with the proliferation and development of proliferation-related marker in prostate cancer
| Project/Area Number |
21592037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIWA Sotarou 金沢大学, 医学系, 協力研究員 (80507070)
MIYAGI Toru 金沢大学, 医学系, 協力研究員 (60467107)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前立腺癌 / アンドロゲン / アンドロゲン感受性 / CAMKK2 |
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| Research Abstract |
We tried identification to affect the androgen receptor sensitivity in the gene which affected the proliferation of the prostate cancer. We compared a gene expression profile by cDNA microarray which we used a normal tissue for with the prostate cancer tissue by several obtained by prostatic needle biopsy. Then we focused on CAMKK2 which the approximately 6 times expression enhanced in patients with cancer in those genes. As for CAMKK2, expression was induced in androgen-sensitive prostate cancer cell line LNCaP by DHT. In immunohistochemical staining of the prostatic tissue and in vitro study, CAMKK2 functioned as antioncogene.
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Research Products
(4 results)
