2010 Fiscal Year Final Research Report
Early assessment of therapeutic effect of molecular targeting agent for treatment of renal cell carcinoma using PET imaging
| Project/Area Number |
21592038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
OYAMA Nobuyuki University of Fukui, 医学部附属病院, 講師 (20223977)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552)
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 泌尿器科学 |
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| Research Abstract |
We assessed the effectiveness of PET imaging for early evaluation of therapeutic effect of molecular targeting agent for metastatic renal cell carcinoma (mRCC). ^<11>C-acetate (AC) PET showed high uptake in most of the metastatic tumor sites, unless the tumor is less than 1 cm. The sensitivity of FDG PET for these mRCC was lower than AC PET. Our study demonstrated that AC PET may be a possible imaging option for assessing the early therapeutic effect of molecular targeting agent for mRCC.
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