2011 Fiscal Year Final Research Report
Analysis of the relation between prostate carcinognenesis targeted stem cells and inflammation
| Project/Area Number |
21592061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Asahi University (2010-2011)
Kanazawa Medical University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Takuji 金沢医科大学, 医学部, 教授 (40126743)
YASUI Yumiko 金沢医科大学, 医学部, 助教 (90434472)
OYAMA Takeru 金沢医科大学, 医学部, 助教 (00515314)
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| Project Period (FY) |
2009 – 2011
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| Research Abstract |
In this study, the relation between prostate carcinogenesis and stem cell or inflammation is analyse in animal experimental carcinogenesis model targeted stem cells associated with prostatitis. Any prostate neoplasma were not found in any castrated rats, although prostate neoplasms was observed only in non-castration groups. From these results, the origin of cancer was assumed to be lost by castration. TP had a suppressive effect in PhIP prostate carcinogenesis. he hypothesis which Prostate cancer originated from stem cell. The lobes with inflammation were different the lobes with PIN. The modifying effect of inflammation for prostate carcinogenesis is not clear, yet. Further consideration will be necessary.
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