Research and regenerative therapy for microcirculation injury in the chemotherapy-affected kidney using biomarkers.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya University
• Principal Investigator: YOSHINO Yasushi 名古屋大学, 医学部附属病院, 講師 (70324415)
• Co-Investigator(Kenkyū-buntansha): GOTOH Momokazu 名古屋大学, 大学院・医学系研究科, 教授 (10186900) ; YAMAMOTO Tokunori 名古屋大学, 医学部附属病院, 講師 (20182636) ; KATO Masashi 名古屋大学, 大学院・医学系研究科, 助教 (10362229)
• Project Period (FY): 2009 – 2011
• Keywords: 化学療法 / 腎機能 / バイオマーカー / 腎微小循環 / シスプラチン / 幹細胞 / 分子標的治療

Research Abstract

The time-intensity curve predicts the ischemic toxicity in the patients undergoing kidney transplantation. It prolonged in the kidney with malignant disease. The time-intensity curve is one of the biomarkers indicating that tumors have malignant components. It also predicts the ischemic toxicity and therapeutic effectiveness on kidneys undergoing target therapy or chemotherapy. Preoperative target therapy using Tyrosine-kinase inhibitor(TKI) was administered for patients with kidney cancer. Histopathological finding indicated TKI decreased the diameter of the small artery in the kidney. Microcirculation is associated with medical effects on tumor shrinkage. The biomarkers indicating microcirculation injury such as the time-intensity curve, liver type fatty-acid binding protein(L-FABP) and enhanced CT findings can be useful predictors of cancer therapy.

Research Products

• [Journal Article] Downsizing a Thrombus of Advanced Renal Cell Carcinoma in a Presurgical Setting with Sora fenib (2011)
  • Author(s): Takeda H, Nakano Y, Kashiwagi Y, Yoshino Y, Gotoh M
  • Journal Title: Urol Int
  • Peer Reviewed
• [Journal Article] Contrast-enhanced ultrasound using a time-intensity curve for the diagnosis of renal cell carcinoma (2010)
  • Author(s): Aoki S, Hattori R, Yamamoto T, Funahashi Y, Matsukawa Y, Gotoh M, Yamada Y, Honda N
  • Journal Title: BJU Int Volume: 108(3)
  • DOI: doi:10.1111/j.1464-410X.2010.09799.x
  • Peer Reviewed
• [Presentation] Usefulness of contrast-enhanced ultrasound using a time-intensity curve for the diagnosis of cystic renal cell carcinoma (2011)
  • Author(s): Aoki S, Nishikawa G, Yoshizawa T, Kato Y, Zennami K, Tobiume M, Nakamura K, Yamada Y, Honda N, Yamamoto T, Hattori R, Gotoh M
  • Organizer: 106^<th> Annual Meeting of American Urological Assosiation
  • Year and Date: 2011-05-18