2011 Fiscal Year Final Research Report
Significance of multiple-drug-resistant Pseudomonas aeruginosa biofilms in the urinary tract as nosocomial infections
| Project/Area Number |
21592073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Shinya 岡山大学, 岡山大学病院, 講師 (30379739)
KOKEGUCHI Susumu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10144776)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 緑膿菌 / 多剤耐性菌 / バイオフィルム / 院内感染症 / 尿路感染症 / 分子疫学 / 院内感染対策 / 新規治療法 |
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| Research Abstract |
Currently, metallo-β-lactamase(MBL)-producing Pseudomonas aeruginosa is the most intractable pathogen in many hospitals. The persistent biofilms formed by MBL-producing P. aeruginosa isolates, which may also be multiple-drug-resistant P. aeruginosa(MDRP), could cause serious problems in nosocomial infections. In this study period, we used newer methods for molecular epidemiological analyses and found valuable evidence for preventing nosocomial infections. In addition, we found promising therapeutic approaches for treating biofilm infections caused by MDRP using novel in vitro and in vivo models.
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Research Products
(23 results)
