2011 Fiscal Year Final Research Report
Functional urethral reconstruction using hollow-fiber cell-culture system
| Project/Area Number |
21592075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
MARUYAMA Tetsuji 名古屋市立大学, 大学院・医学研究科, 研究員 (50305546)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Yoshiyuki 名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
HAYASHI Yutaro 名古屋市立大学, 大学院・医学研究科, 准教授 (40238134)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2009 – 2011
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| Keywords | シェアーストレス / 伸展刺激 / ホローファイバー / 上皮間葉系誘導 / 平滑筋細胞 / 移行上皮細胞 / 再生医療 / 細胞工学 |
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| Research Abstract |
With cytoengineering method, we have made urotherial sheet with functional smooth muscle layer showing regular special pattern. These cells were under laminar flow stimulation exerted shear and stretch stress, and/or electrical stimulation using hollow-fiber cell-culture system. In addition, ES cells were used to induce these urotherial and smooth muscle cell to minimize preparing time and effort.
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