2011 Fiscal Year Final Research Report
GDF-9 as a possible marker for oocyte quality, based on studies of gene expression in rat preantral follciles.
| Project/Area Number |
21592093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Fukui |
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Principal Investigator |
ORISAKA Makoto 福井大学, 医学部・附属病院, 講師 (80324143)
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Katsusige 福井大学, 医学部附属病院, 助教 (60529345)
FUKUDA Sin 福井大学, 医学部, 助教 (40397279)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生殖医学 |
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| Research Abstract |
Polycystic ovary syndrome(PCOS) is commonly associated with ovulatory dysfunction with consequent subfertility, miscarriage, and poor oocyte quality. We have developed an in vitro PCOS model by using rat preantral follicles, and indicated that the gene expressions of oocyte GDF-9 and granulosa FSH receptor are suppressed in this PCOS model. The present results suggest that GDF-9 is a possible marker of oocyte quality in PCOS patients.
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