2011 Fiscal Year Final Research Report
Inhibition of cell proliferation of human endometriotic cells by parthenolide
| Project/Area Number |
21592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tasuku 鳥取大学, 医学部, 教授 (40218649)
IWABE Tomio 鳥取大学, 医学部, 准教授 (10284001)
DEURA Imari 鳥取大学, 医学部附属病院, 助教 (50464293)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬用ハーブ / 子宮内膜症 / パルテノライド / エストロゲン |
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| Research Abstract |
The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for endometriosis.(1) Apigenin suppressed mitogenic activity and PGE2 synthesis in endometriotic stromal cells(ESCs).(2) With parthenolide pretreatment, TNF.-induced IL-8 expression were repressed in ESCs. TNF.-induced COX-2 expression and PGE2 synthesis were also inhibited. Parthenolide suppressed ESCs proliferation by inhibition of NF. B pathway, Using the murine endometriosis model, administrating parthenolide significantly reduced the endometriotic lesions.
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