2011 Fiscal Year Final Research Report
Inhibition of cell proliferation of human endometriotic cells by parthenolide
| Project/Area Number |
21592098
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARADA Tasuku 鳥取大学, 医学部, 教授 (40218649)
IWABE Tomio 鳥取大学, 医学部, 准教授 (10284001)
DEURA Imari 鳥取大学, 医学部附属病院, 助教 (50464293)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 薬用ハーブ / 子宮内膜症 / パルテノライド / エストロゲン |
|---|
| Research Abstract |
The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for endometriosis.(1) Apigenin suppressed mitogenic activity and PGE2 synthesis in endometriotic stromal cells(ESCs).(2) With parthenolide pretreatment, TNF.-induced IL-8 expression were repressed in ESCs. TNF.-induced COX-2 expression and PGE2 synthesis were also inhibited. Parthenolide suppressed ESCs proliferation by inhibition of NF. B pathway, Using the murine endometriosis model, administrating parthenolide significantly reduced the endometriotic lesions.
|
Research Products
(23 results)
