regulation of gonadotropin secretion by novel brain peptides and stresses

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592100
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokushima
• Principal Investigator: MATSUZAKI Toshiya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70294692)
• Co-Investigator(Kenkyū-buntansha): IRAHARA Minoru 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20160070)
• Project Period (FY): 2009 – 2011
• Keywords: 生殖医学 / ゴナドトロピン分泌 / 視床下部 / 神経ペプチド / プログラミング / ストレス / キスペプチン / RFRP

Research Abstract

Expression of novel hypothalamic peptide RFRP increases during development. Suppression of kisspeptin expression by starvation was acquired in neonatal period, and plays an important role for suppression of gonadal function. Stresses during perinatal and neonatal period result in long-lasting influences on sexual function, therefore, it should be better to avoid stresses in tese peropds.

Research Products

• [Journal Article] Effects of lipopolysaccharide exposure at different postnatal time points on the response of LH to homotypic stress in adulthood. (2012)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Nakazawa H, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Reprod Immunol Volume: 94(2) Pages: 155-160
  • DOI: doi:10.1016/j.jri.2012.02.003
  • Peer Reviewed
• [Journal Article] Changes in insulin sensitivity during GnRH agonist treatment in premenopausal women with leiomyoma (2012)
  • Author(s): Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S, Kuwahara A, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
  • Journal Title: Clin Chim Acta Volume: 413(11-12) Pages: 960-965
  • DOI: doi:10.1016/j.cca.2012.01.040
  • Peer Reviewed
• [Journal Article] Okadaic acid-sensitive phosphatase is related to MII/ G1 transition in mouse oocytes (2012)
  • Author(s): Moride N, Kuwahara A, Sutoh A, Tanaka Y, Mukai Y, Yamashita M, Matsuzaki T, Yasui T, Irahara M.
  • Journal Title: Zygote Volume: 20(2) Pages: 193-198
  • DOI: doi:10.1017/S0967199411000013
  • Peer Reviewed
• [Journal Article] Developmental changes in the mammalian gonadotropin-inhibitory hormone(GnIH) ortholog RFamide-related peptide(RFRP) and its cognate receptor GPR147 in the rat hypothalamus. (2011)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Osugi T, Gereltsetseg G, Yoshida S, Irahara M, Tsutsui K.
  • Journal Title: Int J Dev Neurosci Volume: 30(1) Pages: 31-37
  • DOI: doi:10.1016/j.ijdevneu.2011.10.003
  • Peer Reviewed
• [Journal Article] Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats (2011)
  • Author(s): Matsuzaki T, Iwasa T, Kinouchi R, Yoshida S, Murakami M, Gereltsetseg G, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Endocr J Volume: 58(11) Pages: 1003-1012
  • DOI: doi:10.1507/endocrj.K11E-131
  • Peer Reviewed
• [Journal Article] Effect of immune stress on body weight regulation is altered by ovariectomy in female rats (2011)
  • Author(s): Iwasa T, Matsuzaki T, Kinouchi R, Gereltsetseg G, Murakami M, Nakazawa H, Fujisawa S, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Reprod Immunol Volume: 91(1-2 Pages: 41-47
  • DOI: doi:10.1016/j.jri.2011.05.010
  • Peer Reviewed
• [Journal Article] The possibility of vertical transmission of human papillomavirus through maternal milk (2011)
  • Author(s): Yoshida K, Furumoto H, Abe A, Kato T, Nishimura M, Kuwahara A, Maeda K, Matsuzaki T, Irahara M.
  • Journal Title: J Obstet Gynaecol Volume: 31(6) Pages: 503-506
  • DOI: doi:10.3109/01443615.2011.570814
  • Peer Reviewed
• [Journal Article] Induction of circulating monocyte chemoattractant protein-1 in women with gonadotropin-releasing hormone agonist (2011)
  • Author(s): Matsui S, Yasui T, Uemura H, Yamamoto S, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
  • Journal Title: J Reprod Immunol Volume: 90(2) Pages: 227-234
  • DOI: doi:10.3109/01443615.2011.570814
  • Peer Reviewed
• [Journal Article] Changes in responsiveness of appetite, leptin and hypothalamic IL-1βand TNF-αto lipopolysaccharide in developing rats (2011)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Nakazawa H, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Neuroimmunol Volume: 236(1-2) Pages: 10-16
  • DOI: doi:10.1016/j.jneuroim.2011.04.004
  • Peer Reviewed
• [Journal Article] Changes in the responsiveness of serum leptin and hypothalamic neuropeptide Y mRNA levels to food deprivation in developing rats (2011)
  • Author(s): Iwasa T, Matsuzaki T, Kinouchi R, Gereltsetseg G, Murakami M, Nakazawa H, Yasui T, Irahara M.
  • Journal Title: rats. Int J Dev Neurosci Volume: 29(4) Pages: 377-380
  • DOI: doi:10.1016/j.ijdevneu.2011.03.006
  • Peer Reviewed
• [Journal Article] Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1-Kiss1r-GnRH system (2011)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci Volume: 29(2) Pages: 183-188
  • DOI: doi:10.1016/j.ijdevneu.2010.11.001
  • Peer Reviewed
• [Journal Article] Effect of semen characteristics on pregnancy rate following intrauterine insemination (2011)
  • Author(s): Dorjpurev U, Kuwahara A, Yano Y, Taniguchi T, Yamamoto Y, Suto A, Tanaka Y, Matsuzaki T, Yasui T, Irahara M.
  • Journal Title: J Med Invest Volume: 58(1-2) Pages: 127-133
  • DOI: doi:10.2152/jmi.58.127
  • Peer Reviewed
• [Journal Article] Effects of raloxifene on the production of cytokines in stimulated whole blood in ex vivo and in vitro studies (2011)
  • Author(s): Kasai Y, Maegawa M, Yamamoto S, Kamada M, Yasui T, Uemura H, Kobayashi A, Kaneyama M, Tani A, Matsui S, Kuwahara A, Matsuzaki T, Furumoto H, Irahara M.
  • Journal Title: J Med Invest Volume: 58(1-2) Pages: 110-117
  • DOI: doi:10.2152/jmi.58.110
  • Peer Reviewed
• [Journal Article] Does the bromocripti (2011)
  • Author(s): Moride N, Kuwahara A, Yamashita M, Tanaka Y, Matsuzaki T, Yasui T, Irahara M.
  • Journal Title: J Med Invest Volume: 58(1-2) Pages: 63-66
  • DOI: doi:10.2152/jmi.58.63
  • Peer Reviewed
• [Journal Article] Neuropeptide Y mediates orexin A-mediated suppression of pulsatile gonadotropin-releasing hormone secretion in ovariectomized rats (2011)
  • Author(s): Kiyokawa M, Matsuzaki T, Iwasa T, Ogata R, Murakami M, Kinouchi R, Yoshida S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Med Invest Volume: 58(1-2) Pages: 11-18
  • DOI: doi:10.2152/jmi.58.11
  • Peer Reviewed
• [Journal Article] Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats (2010)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Fujisawa S, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Endocrinol Volume: 207(2) Pages: 195-202
  • DOI: doi:10.1677/JOE-10-0129
  • Peer Reviewed
• [Journal Article] Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats (2010)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Fujisawa S, Kinouchi R, Gereltsetseg G, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Physiol Volume: 588(Pt 5) Pages: 821-829
  • DOI: doi:10.1113/jphysiol.2009.183558
  • Peer Reviewed
• [Journal Article] Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri-and postmenopausal women (2010)
  • Author(s): Yasui T, Matsui S, Saijo A, Kaji T, Yamamoto S, Uemura H, Matsuzaki T, Irahara M.
  • Journal Title: Clin Chim Acta Volume: 411(3-4) Pages: 280-284
  • DOI: doi:10.1016/j.cca.2009.11.025
  • Peer Reviewed
• [Journal Article] Neonatal LPS injection alters the body weight regulation systems of rats under non-stress and immune stress conditions (2010)
  • Author(s): Iwasa T, Matsuzaki T, Kinouchi R, Fujisawa S, Murakami M, Kiyokawa M, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci Volume: 28(1) Pages: 119-124
  • DOI: doi:10.1016/j.ijdevneu.2009.08.015
  • Peer Reviewed
• [Journal Article] Hypothalamic Ghrelin suppresses pulsatile secretion of luteinizing hormone via beta-endorphin in ovariectomized rats (2009)
  • Author(s): Ogata R, Matsuzaki T, Iwasa T, Kiyokawa M, Tanaka N, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Neuroendocrinology Volume: 90(4) Pages: 364-370
  • DOI: doi:10.1159/000257421
  • Peer Reviewed
• [Journal Article] Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy (2009)
  • Author(s): Yasui T, Saijo A, Uemura H, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
  • Journal Title: Eur J Endocrinol Volume: 161(2) Pages: 267-273
  • DOI: doi:10.1530/EJE-09-0063
  • Peer Reviewed
• [Journal Article] Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome (2009)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Shimizu F, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: J Obstet Gynaecol Res Volume: 35(3) Pages: 514-519
  • DOI: doi:10.1111/j.1447-0756.2008.00998.x
  • Peer Reviewed
• [Journal Article] Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat (2009)
  • Author(s): Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Ogata R, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci Volume: 27(4) Pages: 345-349
  • DOI: doi:10.1016/j.ijdevneu.2009.03.004
  • Peer Reviewed
• [Presentation] テストステロンに対する特異性を改善した新測定系によるPCOSにおける高テストステロン血症検出率の向上 (2011)
  • Author(s): 松崎利也、木内理世、岩佐武、苛原稔
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20110829-31
• [Presentation] Sensitivities of messenger ribonucleic acid expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats (2011)
  • Author(s): Matsuzaki T, Iwasa T, Kinouchi R, Gereltsetseg G, Irahara M.
  • Organizer: The Endocrine Society' s 93rd Annual Meeting
  • Place of Presentation: Boston Convention & Exhibition Center
  • Year and Date: 20110604-07
• [Presentation] 出生前後の栄養状態およびストレスが成長後の性機能に及ぼす影響シンポジウム「生殖機能の中枢性調節:最近の知見」 (2011)
  • Author(s): 松崎利也、岩佐武、苛原稔
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20110421-23
• [Presentation] 母胎内の低栄養環境は出生後のkisspeptinの作用を低下させ思春期の発来を遅延させる (2010)
  • Author(s): 岩佐武、松崎利也、木内理世、苛原稔
  • Organizer: 第15回日本生殖内分泌学会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 20101120-21
• [Presentation] シンポジウム「見過ごしてならない肥満合併症(婦人科、整形外科、呼吸器科、循環器科)」女性の肥満と月経異常 (2010)
  • Author(s): 松崎利也
  • Organizer: 第3回日本肥満症治療学会学術集会
  • Place of Presentation: 学術総合センター
  • Year and Date: 20100910-11
• [Presentation] Fujisawa S, Kinouchi R, Irahara M. Neonatal LPS Injection Alters the Body Weight Regulation Systems of Rats under Non-Stress and Immune Stress Conditions (2010)
  • Author(s): Matsuzaki T, Iwasa T, Fujisawa S, Kinouchi R, Irahara M.
  • Organizer: The Endocrine Society' s 92nd Annual Meeting
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 20100619-22
• [Presentation] Neonatal lipopolysaccharide exposure attenuates the suppressive responses of LH secretion to homotypic immune challenge in adulthood in male rat. Poster Pressentations ; Reproduction and development 05 (2010)
  • Author(s): Matsuzaki T, Iwasa T, Kinouchi R, Gereltsetseg G, Irahara M.
  • Organizer: The 14th international Congress of Endorinology
  • Place of Presentation: 京都国際会議場
  • Year and Date: 20100326-30
• [Presentation] 多嚢胞性卵巣症候群の診断とホルモン測定上の注意点 (2009)
  • Author(s): 松崎利也
  • Organizer: 第54回日本生殖医学会・学術講演会
  • Place of Presentation: 石川県立音楽堂、ANAクラウンプラザホテル金沢
  • Year and Date: 20091122-23
• [Presentation] Early life lipopolysaccharide expose attenuates the suppressive responses of LH serection to homotypic immune challenge in adulthood in male rat (2009)
  • Author(s): Matsuzaki T, Iwasa T, Kinouchi R, Irahara M.
  • Organizer: The Endocrine Society' s 91st Annual Meeting
  • Place of Presentation: Convention Center
  • Year and Date: 20090610-13
• [Presentation] 新生期のストレスが成熟後のストレスに対する性機能および摂食調節機構の反応に及ぼす影響 (2009)
  • Author(s): 岩佐武、松崎利也、木内理世、村上雅博、苛原稔
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館、前橋商工会議所
  • Year and Date: 20090423-25
• [Presentation] Assessment of serum LH level and LH/ FSH ratio using electrochemistry luminescence immunoassay method for the diagnosis of porycystic ovarysyndrome (2009)
  • Author(s): Matsuzaki T, Kinouchi R, Gereltsetseg G, Fujisawa S, Iwasa T, Irahara M.
  • Organizer: The International Ovarian Conference
  • Place of Presentation: 大手町サンケイプラザ
  • Year and Date: 2009-12-05
• [Presentation] 雄ラットにおいて新生仔期の感染ストレスは成熟後の感染ストレスに対する性機能の反応を減弱させる (2009)
  • Author(s): 岩佐武、松崎利也、藤澤しのぶ、木内理世、苛原稔
  • Organizer: 第14回日本生殖内分泌学会
  • Place of Presentation: シェーンバッハ・サボー
  • Year and Date: 2009-11-28
• [Book] 今日の診断指針第6版 (2010)
  • Author(s): 松崎利也, 他
  • Total Pages: 423-425
  • Publisher: 医学書院