2011 Fiscal Year Final Research Report
Gene mutations flanking tumor-related genes associated with malignant transformation of ovarian endometriosis
| Project/Area Number |
21592104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KITAWAKI Jo 京都府立医科大学, 医学研究科, 教授 (00204925)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮内膜症 / 悪性転化 / 卵巣癌 / loss of heterozygosity / 癌抑制遺伝子 |
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| Research Abstract |
Although ovarian endometriosis follows a benign course, the frequency of the malignant transformation of endometrioma is estimated at about 0.7-1.6%. Here we detected totally 31 loss of heterozygosity events in endometriosis, transitional and carcinoma tissues. Immunohistochemistry revealed that only aromatase was differentially expressed between endometriosis and carcinoma tissues. Our study suggested that LOH in some candidate gene loci may be involved in malignant transformation of endometriosis.
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Research Products
(23 results)
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[Book] 卵子学2011
Author(s)
北脇城
Total Pages
1195, 512-520
Publisher
京都大学学術出版会
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